Showing papers in "The Breast in 2016"

TL;DR: While ER + disease appears to be less immunogenic than HER2+ and triple negative breast cancer, it displays the greatest degree of heterogeneity, and significant differences exist in both the genomic and immune characteristics amongst breast cancer subtypes.

TL;DR: For women with ≥5 nodes removed, arm swelling in the first year poses a very strong risk for presence of LE at 18-months, while arm swelling at 6 and 12 months was associated with taxane-based chemotherapy, high body weight at diagnosis and arm swelling within 4 weeks post-surgery.

TL;DR: It is proposed that responses of cancer cells to drugs are not exclusively determined by their intrinsic characteristics but are also controlled by deriving signals from tumor microenvironment, which modifies responses to chemotherapy in breast cancer.

TL;DR: CESM has a high sensitivity but very low specificity and high-quality studies are required to assess the accuracy of CESM in unselected cases.

TL;DR: Summary: Decision aids are available and improved decision-related outcomes for many breast cancer treatment decisions including surgery, radiotherapy, and endocrine and chemotherapy, including neoadjuvant systemic therapy and contralateral prophylactic mastectomy can be found.

TL;DR: Results indicate ribociclib plus letrozole may reduce Ki67 expression in HR+, HER2- BC and suggest absence of a drug-drug interaction between ribciclib and letroZole is suggested.

TL;DR: The increased depth of mutation detection brought by next-generation sequencing and a better understanding of the mechanisms through which these mutations cause the disease will bring novel insights in terms of oncological prevention, diagnostics, and therapeutic options for HBC patients.

TL;DR: Findings improve the understanding of the expression pattern of LDHA and AMPK in breast cancer and clarify the role of LD HA and AM PK as promising prognostic biomarkers for breast cancer.

TL;DR: Surgical and oncological results show that NSM is effective and a comparison of results with no geographical differences and a "safe" state of the art of NSM in Italy is enabled.

TL;DR: The St. Gallen 5-tyre surrogate classification for breast cancer subtypes accurately predicts breast cancer presenting features (with emphasis on prediction of nodal involvement), recurrence patterns and disease free survival.

TL;DR: MRI scanning consistently demonstrated the highest accuracy with three studies reporting errors lower than 10% for small, medium and large breasts, however, as a high-cost, non-routine assessment other methods may be more appropriate.

TL;DR: DBT, as an adjunct to FFDM, has a higher cancer detection rate, increasing the effectiveness of breast cancer screening, and additional benefits of DBT may also include reduced recalls and, consequently, reduced costs and distress caused to women who would have been recalled.

TL;DR: The quality of breast cancer information on the internet is on the whole good; however the range of quality is wide, and healthcare professionals are recommended to use all 3 tools together to establish which websites are best to advise which websites patients should trust.

TL;DR: AIs are superior to TAM as adjuvant hormonal therapy for postmenopausal ER-positive breast cancer and TAM can be considered for individual patients due to the different toxicity profile compared with AI.

TL;DR: Young women find decision-making challenging when the characteristics of diagnosis provide a surgical choice between mastectomy and breast conservation surgery, and efforts should be made to provide information regarding sexuality, body image, reconstruction, fertility and likelihood of familial predisposition.

TL;DR: SBRT is a safe and feasible alternative treatment of liver and lung oligometastases from breast cancer, in selected patients not amenable to surgery, with good local control and survival rate.

TL;DR: Overall, women appeared satisfied with CPM, however, adverse/diminished body image, poor cosmetic result, complications, diminished sense of sexuality, emotional issues and perceived lack of education regarding alternative surveillance/CPM efficacy were cited as reasons for dissatisfaction.

TL;DR: The results highlight that oncology health professionals should take into account not only the individual and medical characteristics, but also the stage of the oncological process and the psychosocial environment of patients in order to promote their positive functioning.

TL;DR: Findings of this review suggest that changes in expression of proteins in breast cancer cells that confer osteomimicry facilitate homing to bone to enable the development of bone metastasis.

TL;DR: Precision assessment of heterogeneity of lymphedema phenotype and understanding the biological mechanism of each phenotype through the exploration of inherited genetic susceptibility is essential for finding a cure.

TL;DR: The results confirm that BNP could be a useful minimally invasive marker of early RT related cardiac impairment in women with left-sided breast cancer.

TL;DR: Prevalence rate of lymphedema and other upper limb impairments may not be underestimated after SLNB, and pain, shoulder range of motion, handgrip strength and shoulder function change significantly up to one year compared to preoperative values in sentinel node-negative breast cancer patients.

TL;DR: It is demonstrated that surgical patients with less information reported significantly lower anxiety, and the thorough testing and auditing of information initiatives before deployment is advised.

TL;DR: Solid papillary carcinoma of the breast is a rare entity with distinctive clinicopathological features and excellent prognosis and should be distinguished from conventional breast carcinoma to avoid over-treatment.

TL;DR: Although medical advances have marginally improved survival of women with advanced breast cancer, their psychosocial, emotional, and functional needs remain unmet and concerted efforts by people who care for and support women withAdvanced breast cancer are urgently needed.

TL;DR: In conclusion, physical self-management interventions during breast cancer treatment as well as after the primary treatment seem to generate beneficial effects on QoL.

TL;DR: Stronger evidence than currently available is needed on the safety of foregoing axillary dissection in well-defined populations of patients with positive SLNs and the Italian multicentre SINODAR ONE randomized trial presented was designed with this aim.

TL;DR: In order to accelerate progress towards precision treatment for women with breast cancer, the authors need additional predictive biomarkers, especially for enhancing the positive predictive value for endocrine and anti-HER2 therapies, as well as biomarkers for predicting response to specific forms of chemotherapy.

TL;DR: In the survival analysis, cats with Luminal A subtype presented the highest survival time and animals with triple negative basal-like subtype exhibited the lowest survival time, revealing that feline can be a valuable model for comparative studies.

TL;DR: This study provides evidence that women are willing to accept the potential risks of IIBR in exchange for its benefits including enhanced body image during chemotherapy and PMRT and the possible avoidance of more complicated and costly delayed autologous BR.