Showing papers in "Toxicology Letters in 1979"

TL;DR: The studies indicate potential sites of toxic action Pd 2+ as well as its inhibitors, inhibiting creatine kinase (CPK) and prolyl hydroxylase (Ki app = 20.0 μ M).

TL;DR: In this article, the reactivity of simple epoxides with 4-(p -nitrobenzyl)-pyridine was compared with their mutagenicity in Salmonella typhimurium TA 100 and Escherichia coli WP 2 uvrA.

TL;DR: Dimethylarsinic acid (DMAA), the major metabolite was detected in the plasma and red blood cells within 50 min after dosing and was present as DMAA in blood and urine samples analysed for arsenic metabolites.

TL;DR: Results demonstrated that although vital signs and histaminase activity showed no consistent pattern of change at any histamine dose, characteristic symptoms of scombroid poisoning were noted at the 100-mg doses of histamine.

TL;DR: In C3H mice, rate of hepatic metallothionein synthesis was significantly lower than in BALB/c or DBA/2, and it was clarified that the mortality from Cd-intoxication is determined by the amounts of hepatocellulose, the induction of which depends on genetic predisposition.

TL;DR: Altered levels of copper and calcium did not appear to be related to the altered metabolism of catecholamines in the brain and altered levels of manganese were found in male Rhesus monkeys.

TL;DR: The effect of 2 cardiotoxic anthracycline antibiotics on rat heart mitochondria was investigated in vitro and in vivo, finding that rubidazone was a potent uncoupler of oxidative phosphorylation and Doxorubicin caused marked inhibition of electron transfer reactions.

TL;DR: The Ames Salmonella/mammalian microsome assay system was used to evaluate the mutagenic potential of some of the proposed metabolites of Direct Black 38 and Pigment Yellow 12, and it was found that dichlorobenzidine, monoacetylbenzidine and the urine from the animals treated with Direct Black38 were active in the Ames test only after S-9 fraction was added to the test mixture.

TL;DR: In this article, the liver of rainbow trout was found to contain a cadmium-binding protein of about 6700 daltons and with greater absorbance in the ultraviolet at 250 nm than at 280 nm.

TL;DR: Fetotoxicity of di-(2-ethylhexyl)phthalate was studied in a random strain of mice and a straight line Y = 51.9 log X + 61.6 was obtained where Y = the rate of death(%) and X = the dose of DEHP administered (ml/kg).

TL;DR: It is suggested that placental AHH be used as a measure of foetal exposure to maternal cigarette smoking.

TL;DR: Male rats were employed to study the blood and liver cyanide concentrations after oral doses of 6, 10 and 14 mg potassium cyanide (KCN)/kg body weight, and liver CN concentrations were generally lower than the corresponding blood CN concentration for all dosage groups studied.

TL;DR: Large amounts of arsenic were administered to some monkeys over a 12-month period without inducing clinical or pathological effect, and without accumulation of arsenic in the tissues, there is no evidence to indicate that delayed arsenic poisoning is a reality.

TL;DR: The histopathological effects of the glycoalkaloids included severe renal and hepatic congestion and leukocytic infiltration and Renal tubular degeneration and liver centrilobular necrosis were evident in mice treated with extracts of A. solani.

TL;DR: The in vitro activity of the 2-amino-6methyl-dipyrido[l,2-a:3',2'-d]imidazole (Glu-P-1) was examined in a transformation assay with cryopreserved hamster embryo cells as discussed by the authors.

TL;DR: The increase in erythrocyte ALAD activity was found to be significantly linearly correlated with the increase in blood zinc concentrations, and in comparison with control subjects, the patients had significantly lower activities of ALAD and significantly increased serum aluminium concentrations.

TL;DR: Manganese chloride was administered intraperitoneally daily to guinea pig pups from the second day after birth for 30 days and a marked decrease in serum tryptophan was associated with reduced levels of brain 5-HT and 5-HIAA in manganese-treated animals.

TL;DR: There was an inverse relationship between the concentration of lead nitrate and the fall in liver, muscle and brain glycogen and the levels of serum glucose and lactate, which were higher in the major carps than in catfish or murrels.

TL;DR: In this article, the carcinogen N-nitrosodiethanolamine (NDElA) was detected by its appearance in the urine of a human wearing a contaminated facial cosmetic.

TL;DR: Aqueous solutions of amine-buffers (e.g., Tris and 2(N-morpholino)ethane-sulfonic acid) removed ozone from a stream of gas as demonstrated by differential spectrophotometry as discussed by the authors.

TL;DR: Administration of the dose of monosodium l -glutamate as a solution in infant formula or as a paste in synthetic diet markedly suppressed elevation of plasma glutamate and induction of hypothalamic lesions.

TL;DR: The results indicate that the enzymatic activities of horse liver alcohol dehydrogenase and bovine pancreatic trypsin depend on the level of substitution of mercury compounds, and the SH-enzyme was found to be more sensitive to every mercury compound tested than the non-SH enzyme.

TL;DR: Tri- n -butyl lead acetate at concentrations of 5.10 −5 -10 −7 M was effective in inhibiting high affinity uptake and in stimulating release of accumulated radioactive putative neurotransmitters by mouse brain homogenates, suggesting that dopaminergic synapses are especially susceptible to such toxicity.

TL;DR: It is concluded that (+)-cyanidanol-3 prevents the lipid peroxidation induced in vivo by CBrCl 3 .

TL;DR: In this article, the authors showed that both DMF and DMSO prolonged significantly ethanol-induced loss of righting reflex in mice, but not barbital-induced righting response.

TL;DR: All of the arsenic was excreted in the urine, while less than 5% was recovered in the feces, which indicates that the whole body retention and excretion of inorganic arsenic is low.

TL;DR: Foetal eye melanin in pigmented mice showed much greater accumulation of injected nicotine- d -bitartrate than maternal eye melanIn conclusion, nicotine seems to be accepted as a precursor in the formation of new melanin, due possibly to a structural resemblance to the main precursor of melan in indole-5,6-quinone.

TL;DR: Induction by Empire Mix oil increased with time of exposure but induction by Saudi Arabian oil remained about the same with time, and induction of microsomal components was greater for Saudi ArabianOil at one week of exposure than for Empire Mix at three weeks.

TL;DR: Rats exposed to an aerosol of cadmium oxide for up to 1 year postexposure exhibited a statistically significant increase in blood pressure, blood glucose levels, urinary protein, and in the incidence of seminiferous tubule degeneration, suggesting that chronic toxicity of inhaled cadMium oxide may be manifest in organ systems other than the lung.

TL;DR: The primitive fishes (major carp) appear less resistant than snake-headed or cat fish to face environmental change and the observed physiological and biochemical variations due to zinc intoxication are discussed.