Showing papers in "Transfusion in 2013"

TL;DR: In Afghanistan, a substantial portion of resuscitative combat surgery is performed by US Army forward surgical teams (FSTs), and red blood cells and fresh frozen plasma are available but platelets are not.

TL;DR: It is hypothesized that refrigeration preserves WB function and that a pathogen reduction technology (PRT) based on riboflavin and ultraviolet light has no deleterious effect over 21 days of storage.

TL;DR: A large series of orthopedic surgical patients were studied for possible relations between IV iron, ABT, and PNI to address potential concerns about IV iron and the risk of PNI.

TL;DR: This review summarizes the current understanding of the pathophysiology of ATC and the role of rapid diagnostics in the management of severe trauma hemorrhage and considers diagnostic and therapeutic strategies for bleeding trauma patients with short versus long prehospital times and the concept of remote damage control resuscitation.

TL;DR: The increasing use of fresh blood group O whole blood in acute trauma medicine makes it important to reevaluate the issue of hemolytic reactions related to the transfusion of ABO‐incompatible plasma.

TL;DR: Hemocoagulative disorders after TBI may be amenable to treatment, and adequate and timely management may protect from secondary injury and poor outcomes.

TL;DR: Many patients receiving oral iron for iron deficiency anemia (IDA) cannot tolerate or fail to respond to therapy, and existing intravenous (IV) iron formulations often require repeated administrations.

TL;DR: RBC microparticles produced during storage have been identified as biomarkers of RBC quality, being potentially immunogenic and inhibitory to nitric oxide regulation.

TL;DR: Occult hepatitis B virus (HBV) infection (OBI) is identified in 1:1000 to 1:50,000 European blood donations and the infectivity of blood products from OBI donors is determined.

TL;DR: Red blood cell–derived microparticles are small phospholipid vesicles shed from RBCs in blood units, where they accumulate during storage, and could be suggested that RMPs are mediators of posttransfusion complications or, on the contrary, constitute a potential hemostatic agent.

TL;DR: This research highlights the need to understand more fully the role of language in the formation of memory and the role that language plays in the development of memory impairment.

TL;DR: The presence of a chikungunya virus (CHIKV) outbreak could have an impact on transfusion safety when there are a large number of infected persons during an epidemic, but the viremic profiles of asymptomatic chikunya patients, the major determinant of the transfusion risk, are unknown.

TL;DR: Hemorrhage accounts for most preventable trauma deaths, but still the optimal strategy for hemostatic resuscitation remains debated.

TL;DR: Platelet (PLT) gels exhibit antimicrobial activity useful for wound healing and the nature of the antibacterial component(s) is unknown.

TL;DR: Hepatitis E virus (HEV) infection has become relevant to blood transfusion practice because isolated cases of blood transmission have been reported and because HEV has been found to cause chronic infection and severe liver disease in immunocompromised patients.

TL;DR: Thrombopoietin receptor agonists are effective treatments for immune thrombocytopenia, however, continuous therapy is generally required to maintain platelet (PLT) count responses.

TL;DR: The data, obtained from overseas operations, confirmed the indications, the safety and the clinical efficacy of FLYP and further research is needed to determine specific indications for FLYP in the therapeutic management of civilian patients with severe hemorrhage.

TL;DR: In this article, the authors describe innovative methods for analyzing and presenting data for red blood cell (RBC) utilization that compare hemoglobin (Hb) transfusion triggers and targets to those representing the restrictive transfusion strategy advocated by previous large outcome studies.

TL;DR: The current value of all HBV tests, the HBV residual risk before and after the introduction of MP‐NAT, and estimated residual risks with further improvements in HBV screening for US blood donations are evaluated.

TL;DR: Transfusion of red blood cells is frequently required for care of individuals with sickle cell disease and alloimmunization rates are high and may be reduced by matching for RBC antigens that can cause alloIMmunization.

TL;DR: New research supports the notion that during NK-cell maturation, an education or licensing event occurs that allows NK cells to adapt to their environment, a feature of the adaptive immune response, and the definition and functional characteristics of NK cells will be further refined.

TL;DR: This data indicates that admission platelet counts are known to be associated with all‐cause mortality for seriously injured patients admitted to a trauma center and the course of subsequent PLT counts, their implications, and the effects of PLT therapy are less well known.

TL;DR: The current prevalence of cytomegalovirus (CMV) in Japan and the risk of CMV transfusion transmission are unknown in the era of seronegative leukoreduced blood components.

TL;DR: Consensus‐based recommendations ameliorate the appropriateness in daily clinical practice and, in turn, optimize the use of health care resources.

TL;DR: Nucleic acid amplification testing for hepatitis B virus (HBV) during blood screening has helped to prevent transfusion‐transmitted HBV infection (TT‐ HBV) in Japan, Nevertheless, 4 to 13 TT‐HBV infections arise annually.

TL;DR: The American Red Cross began preferentially distributing plasma from male donors in 2007 and subsequently observed an 80% decrease in reported cases of transfusion‐related acute lung injury (TRALI) after plasma transfusion, and the ongoing risk of TRALI and the ABO blood group of involved plasma donors was evaluated.

TL;DR: Pica and restless legs syndrome are associated with iron depletion and deficiency and the presence of pica and RLS was prospectively assessed in blood donors.

TL;DR: The objective was to determine and compare to Food and Drug Administration criteria the PLT recovery and survival of autologous PLTs cryopreserved at −65°C or less in 6% dimethyl sulfoxide (DMSO) reconstituted with a no‐wash method (cryopreserve PLTs [CPPs].

TL;DR: This study aimed at determining the characteristics of RBC alloimmunization in transfusion‐dependent patients with myelodysplastic syndrome or chronic myelomonocytic leukemia (MDS/CMML).

TL;DR: Identification of donor characteristics correlating with higher CBU quality could guide operational strategies to increase the yield of banked high‐quality CBUs.