Showing papers in "Trends in Biochemical Sciences in 1991"

TL;DR: It is suggested in this review that, despite this diversity of nuclear targeting sequences, a consensus bipartite motif can be identified.

TL;DR: Structural analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.

TL;DR: The evidence leading to the suggestion that the free pool of one of these proteins, hsp70, serves as a cellular thermometer that regulates the expression of all heat shock proteins is reviewed.

TL;DR: The 310-helix, first predicted as a reasonably stable polypeptide secondary structure fifty years ago, has only recently attracted the attention of structural biochemists and protein crystallographers.

TL;DR: RGD peptides and mimetics, in addition to providing insights into the fundamental mechanisms of cell adhesion, are potential therapeutic agents for the treatment of diseases such as thrombosis and cancer.

TL;DR: The chromogranins/secretog Granins are a family of acidic secretory proteins that are found in the secretory granules of a wide variety of endocrine cells and neurons, being stored together with many different peptide hormones and neuropeptides.

TL;DR: A consensus amino acid sequence for this motif has aided the identification of new members of this family of EF-hand proteins, which now has about 170 members.

TL;DR: The recently discovered TPR gene family encodes a diverse group of proteins that function in mitosis, transcription, splicing, protein import and neurogenesis.

TL;DR: Individual steps in the assembly of RNA polymerase II and general initiation factors into a preinitiation complex serve as points of control for activators, whose functions require additional cofactors.

TL;DR: A number of enzymes employ the unusual amino acid selenocysteine as part of their active site because of its high chemical reactivity and represents a unique expansion of the genetic code.

TL;DR: In the drawings presented here, I have attempted to combine molecular composition data with structural results for a well studied organism, Escherichia coli.

TL;DR: It is suggested that the chlorophyll a/b-binding polypeptides may be involved in pigment biosynthesis or in assembly of the thylakoid membrane.

TL;DR: In this review, the contributions that heterotypic dimerization may make to the generation of regulatory diversity are explored.

TL;DR: X-ray crystallography has revealed the molecular architecture of the cellular and oncogenic forms of p21Ha-ras, the protein encoded by the human Ha-ras gene, in both its active and inactive forms, suggesting that p21ras can serve as a good model for other guanine nucleotide binding proteins.

TL;DR: Release of HS-bound bFGF by heparin-like molecules and HS-degrading enzymes provides a novel mechanism for regulation of the growth of capillary blood vessels in normal and pathological situations.

TL;DR: There is evidence that these collagens may serve as molecular bridges that are important for the organization and stability of extracellular matrices.

TL;DR: Stathmin is a ubiquitous, phylogenetically conserved protein present in the cytoplasm of cells in a variety of unphosphorylated and phosphorylated forms, and a good candidate as a general relay in signal transduction, possibly integrating diverse signals of the cell's environment.

TL;DR: These functional domains are not in other actin-crosslinking proteins, one of which is elongation factor 1a (EF-1a) suggesting there are several pathways for the evolution of actin's crosslinking function.

TL;DR: Transcriptional regulatory factors from different families interact with each other when bound to DNA at composite response elements, and closely related factors from a given family can produce very different regulatory patterns.

TL;DR: A group of unusually acidic proteins and glycoproteins can interact specifically with some crystal faces but not others, induce oriented nucleation, or intercalate in a regular manner into the crystal lattice itself.

TL;DR: An evaluation of the secondary structures suggest that common secondary structures may be employed by most of the toxic PFPs isolated from a wide array of species ranging from humans to bacteria.

TL;DR: Inhibitors of the calcium-dependent cysteine protease calpain are described that are new analogs of the naturally-occurring compounds E-64 and leupeptin, which can inhibit calpain within cells.

TL;DR: Activation of phospholipase C-γ 1 through tyrosine phosphorylation provides a link between mitogenic and inositolospholipid signaling.

TL;DR: Kinetic, functional and sequence information reveals that rhodopsin kinase and beta ARK are closely related, suggesting they may be members of a family of G-protein-coupled receptor kinases.

TL;DR: From their hybrid properties, the reaction centres of green sulphur bacteria and heliobacteria seem to be the missing links between the two branches of the reaction centre family, typified by higher plant photosystem I and the purple bacterial reaction centre.

TL;DR: A number of prokaryotic enhancer-binding proteins activate transcription by specialized forms of RNA polymerase, but one class contacts its cognate polymerase by DNA loop formation while the other does not and both must hydrolyse ATP to catalyse open complex formation.

TL;DR: Two transcriptional regulators are reviewed, ArcA and FNR, which control the expression of networks of genes in response to oxygen limitation, which ensure that the most energetically favourable metabolic mode is adopted in a specific environment.

TL;DR: Many proteins have the ability to bind to a variety of DNA sequences, the recognition of which depends on some general rather than specific feature of the DNA.

TL;DR: In mammalian mitochondrial DNA, activation of the light-strand promoter mediates both priming of leading-Strand replication and initiation of light- Strand transcription.