Journal ArticleDOI
1H MR Spectroscopy of the Brain: Absolute Quantification of Metabolites
Reads0
Chats0
TLDR
Important methodological aspects in an absolute quantification strategy are addressed, including radiofrequency coil properties, calibration procedures, spectral fitting methods, cerebrospinal fluid content correction, macromolecule suppression, and spectral editing.Abstract:
Hydrogen 1 (1H) magnetic resonance (MR) spectroscopy enables noninvasive in vivo quantification of metabolite concentrations in the brain. Currently, metabolite concentrations are most often presented as ratios (eg, relative to creatine) rather than as absolute concentrations. Despite the success of this approach, it has recently been suggested that relative quantification may introduce substantial errors and can lead to misinterpretation of spectral data and to erroneous metabolite values. The present review discusses relevant methods to obtain absolute metabolite concentrations with a clinical MR system by using single-voxel spectroscopy or chemical shift imaging. Important methodological aspects in an absolute quantification strategy are addressed, including radiofrequency coil properties, calibration procedures, spectral fitting methods, cerebrospinal fluid content correction, macromolecule suppression, and spectral editing. Techniques to obtain absolute concentrations are now available and can be suc...read more
Citations
More filters
Book ChapterDOI
MR spectroscopic studies of the brain in psychiatric disorders.
TL;DR: Findings of reduced NAA in specific brain regions in schizophrenia, bipolar disorder, post-traumatic stress disorder, and obsessive–compulsive disorder corroborate findings of reduced brain volumes in the same regions and are consistent with metabolic models of pathogenesis in those disorders.
Book ChapterDOI
Energy Metabolism of the Brain
TL;DR: Brain activity, metabolic demand, and blood flow rate (to deliver fuel and remove by-products) are very closely linked at a local level.
Journal ArticleDOI
GABA estimation in the brains of children on the autism spectrum: measurement precision and regional cortical variation
William Gaetz,Luke Bloy,Dah Jyuu Wang,Russell G. Port,Lisa Blaskey,Susan E. Levy,Timothy P.L. Roberts +6 more
TL;DR: The novel findings support the model of regional differences in GABA+/Cr in the ASD brain, primarily in Auditory and to a lesser extent Motor but not Visual areas.
Journal ArticleDOI
Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain
TL;DR: This review summarizes the neurometabolite abnormalities found in MRS studies performed in patients with neuroinflammatory disorders or neuropathic pain, which also may be associated with neuroinflammation.
Journal ArticleDOI
Quantification of Liver Fat Content: Comparison of Triple-Echo Chemical Shift Gradient-Echo Imaging and in Vivo Proton MR Spectroscopy
Boris Guiu,Jean-Michel Petit,Romaric Loffroy,Douraied Ben Salem,Serge Aho,David Masson,Patrick Hillon,Denis Krausé,Jean-Pierre Cercueil +8 more
TL;DR: A breath-hold triple-echo gradient-echo sequence with a low flip angle and correction for T2* decay is accurate for quantifying fat in segment VII of the liver and could replace (1)H MR spectroscopy in longitudinal studies.
References
More filters
Book
Principles of nuclear magnetic resonance in one and two dimensions
TL;DR: In this paper, the dynamics of nuclear spin systems were studied by two-dimensional exchange spectroscopy and nuclear magnetic resonance imaging (NEMI) imaging, and two different correlation methods based on coherence transfer were proposed.
Journal ArticleDOI
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
TL;DR: The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model spectra of metabolite solutions in vitro by using complete model spectra, rather than just individual resonances, to ensure maximum information and uniqueness are incorporated into the analysis.
Journal ArticleDOI
Proton NMR chemical shifts and coupling constants for brain metabolites.
TL;DR: Proton NMR chemical shift and J‐coupling values are presented for 35 metabolites that can be detected by in vivo or in vitro NMR studies of mammalian brain, with an accuracy suitable for computer simulation of metabolite spectra to be used as basis functions of a parametric spectral analysis procedure.
Journal ArticleDOI
Improved Method for Accurate and Efficient Quantification of MRS Data with Use of Prior Knowledge
TL;DR: AMARES (advanced method for accurate, robust, and efficient spectral fitting), an improved method for accurately and efficiently estimating the parameters of noisy magnetic resonance spectroscopy (MRS) signals in the time domain, is introduced.
Journal ArticleDOI
The signal-to-noise ratio of the nuclear magnetic resonance experiment
D.I Hoult,Rex Edward Richards +1 more
TL;DR: A fresh approach to the calculation of signal-to-noise ratio, using the Principle of Reciprocity, is formulated, to give the same results as the traditional method of calculation, but its advantage lies in its ability to predict the ratio for other coil configurations.