Journal ArticleDOI
[2+2] Cycloaddition of electron-poor acetylenes to (E)-3-dimethylamino-1-heteroaryl-prop-2-en-1-ones: synthesis of highly functionalized 1-heteroaroyl-1,3-butadienes
Jure Bezenšek,Tanja Kolesa,Uroš Grošelj,Jernej Wagger,Katarina Stare,Anton Meden,Jurij Svete,Branko Stanovnik +7 more
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TLDR
Microwave-assisted cycloaddition of (E)-3-dimethylamino-1-heteroaryl-prop-2-en-1ones to dimethyl acetylenedicarboxylates gives (2E,3E)-dimethyl-2-[(dimethyamino)methylene]-3-(substituted)succinates in 8-91% yield as mentioned in this paper.About:
This article is published in Tetrahedron Letters.The article was published on 2010-06-30. It has received 37 citations till now. The article focuses on the topics: Cycloaddition & Succinates.read more
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Synthesis of polysubstituted dihydropyridines by four-component reactions of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate.
TL;DR: A practical and efficient procedure for the preparation of the polysubstituted dihydropyridines was developed through a unique four-component reaction of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate in ethanol in the presence of triethylamine as a base promoter.
Journal ArticleDOI
Molecular Diversity of Three‐Component Reactions of Aromatic Aldehydes, Arylamines, and Acetylenedicarboxylates
TL;DR: The three-component reactions of aromatic aldehydes, arylamines, and acetylenedicarboxylates show very interesting molecular diversity as discussed by the authors, and the reaction mechanism for the formation of the three products is briefly explained.
Journal ArticleDOI
Synthesis of 3,4-dihydropyridin-2(1H)-ones and 3,4-dihydro-2H-pyrans via Four-component reactions of aromatic aldehydes, cyclic 1,3-carbonyls, arylamines, and dimethyl acetylenedicarboxylate.
TL;DR: The key steps are proposed to involve Michael addition of the enamino ester formed in situ from the reaction of arylamine with dimethyl acetylenedicarboxylate to arylidine cyclic 1,3-diketones.
Journal ArticleDOI
Selective Synthesis of Fused 1,4‐ and 1,2‐Dihydropyridines by Domino Reactions of Arylamines, Acetylenedicarboxylate, Aldehydes, and Cyclic 1,3‐Diketones
TL;DR: In this paper, a practical procedure for the preparation of fused 1,4-dihydropyridines was developed through the domino four-component reactions of arylamines, acetylenedicarboxylate, aromatic aldehydes, and cyclic 1,3-diketones in acetic acid.
Journal ArticleDOI
A simple metal-free synthesis of 2-substituted pyridine-4,5-dicarboxylates and their N -oxides
TL;DR: In this paper, a simple metal-free synthesis of 2-alkyl, 2-cycloalkyl-, 2-aryl-, and 2-heteroaryl-substituted pyridine 3,4-dicarboxylates and their N-oxides from the corresponding methyl ketones in good to excellent yield, demonstrated with 22 examples in each case, is described.
References
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Book ChapterDOI
Processing of X-ray diffraction data collected in oscillation mode
Zbyszek Otwinowski,Wladek Minor +1 more
TL;DR: The methods presented in the chapter have been applied to solve a large variety of problems, from inorganic molecules with 5 A unit cell to rotavirus of 700 A diameters crystallized in 700 × 1000 × 1400 A cell.
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SIR97: a new tool for crystal structure determination and refinement
Angela Altomare,Maria Cristina Burla,Mercedes Camalli,Giovanni Luca Cascarano,Carmelo Giacovazzo,Antonietta Guagliardi,Anna Moliterni,Giampiero Polidori,Riccardo Spagna +8 more
TL;DR: SIR97 is the integration of two programs, SIR92 and CAOS, the first devoted to the solution of crystal structures by direct methods, the second to refinement via least-squares–Fourier procedures.
ReportDOI
ORTEP-III: Oak Ridge Thermal Ellipsoid Plot Program for crystal structure illustrations
M.N. Burnett,C.K. Johnson +1 more
TL;DR: In this paper, a computer program for drawing crystal structure illustrations is described, which can also produce stereoscopic pairs of illustrations which aid in the visualization of complex packing arrangements of atoms and thermal motion patterns.
Journal ArticleDOI
Synthesis of heterocycles from alkyl 3-(dimethylamino)propenoates and related enaminones.
Branko Stanovnik,Jurij Svete +1 more
Journal ArticleDOI
Recent advances in enantioselective [2 + 2 + 2] cycloaddition
TL;DR: This short account discloses the recent results of inter- and intramolecular enantioselective cycloadditions of alkyne and/or alkene moiety using chiral transition metal catalysts.