Book ChapterDOI
3 Some Pyrimidines of Biological and Medicinal Interest—Part III
C.C. Cheng,Barbara Roth +1 more
TLDR
Pyrimidines containing two ethylenimine functions have also been found to possess anticancer activity, and 2, 4-Bis (aziridinyl)-6-chloropyrimidine (CV, ethymidine, etimidin) significantly inhibits growth of many transplantable mouse and rat tumours.Abstract:
Publisher Summary This chapter lists some pyrimidines of biological and medicinal interest, including 5-hydroxypy rimidines, barbituric acid and its derivatives, aminohydroxypyrimidines, pyrimidine amino acids, and nitro and nitrosopyrimidines. The chapter also discusses pyrimidines containing biological alkylating functions. A large number of derivatives of the original nitrogen mustard and other biological akylating agents, such as ethylenimines and epoxides have been prepared as potential anticancer agents. The chapter further explains that the alkylating agents consist of a carrier and the alkylating group, and that differences in selectivity of action upon the tumour, or ability to reach the site of desired action, with minimum damage to the host, are dependent upon the carrier. The chapter also reviews that some pyrimidines containing two ethylenimine functions have also been found to possess anticancer activity. 2, 4-Bis (aziridinyl)-6-chloropyrimidine (CV, ethymidine, etimidin) significantly inhibits growth of many transplantable mouse and rat tumours.read more
Citations
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Journal ArticleDOI
Diabetes induces apoptosis in lymphocytes.
TL;DR: A high proportion of apoptotic lymphocytes in diabetic states may explain the impaired immune function in poorly controlled diabetic patients, and the involvement of low insulinaemia for the occurrence of apoptosis in lymphocytes was examined.
Journal ArticleDOI
A review: biological and clinical aspects of pyrimidine metabolism.
TL;DR: The broad biologic aspects of pyrimidine nucleotide biosynthesis are reviewed, which include the role of sugar and phospholipid carriers, and the importance of these interrelations is most forcibly emphasized by certain clinical phenomena which will be discussed later.
Journal ArticleDOI
Synthesis and antimicrobial activity of 6,7-annulated pyrido[2,3-d]pyrimidines.
TL;DR: Four new 6H-indeno[2',1':5,6]pyrido[2,3-d]pryimidines (10-13) were synthesized via cyclocondensation reactions involving chlorovinyl aldehyde 1 or ketoaldehyde 3 and appropriately substituted 6-aminopyrimidines and moderate antimicrobial activity was observed for some of these compounds.
Journal ArticleDOI
Progress with antiviral agents
TL;DR: This brief outline concentrates on only a limited range of compounds, mainly nucleoside and poly(nucleotide) analogues, principally with a view to illustrating the feasability of designing broad-spectrum antiviral agents.
References
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Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
James D. Watson,Francis Crick +1 more
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Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III
TL;DR: A reprint of Avery, MacLeod, and McCarty's article on the 35th anniversary of its original publication.
Journal Article
Pharmacological implications of microsomal enzyme induction
TL;DR: It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome.
Journal ArticleDOI
Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage.
Alfred Day Hershey,Martha Chase +1 more
TL;DR: All types of evidence show that the passage of phage DNA into the cell occurs in non-nutrient medium under conditions in which other known steps in viral growth do not occur.
Journal ArticleDOI
The Significance of Pneumococcal Types.
TL;DR: In the course of the examination of sputum from cases of lobar pneumonia, observations have been made on the incidence of the chief types of pneumococci, and the antigens of certain Group IV strains appear to be closely related to that of Type II.