Journal ArticleDOI
50 years of research on α-amino-β-methylaminopropionic acid (β-methylaminoalanine)
TLDR
The isolation of α-amino-β-methylaminopropionic acid from seeds of Cycas circinalis (now C. micronesica Hill) resulted from a purposeful attempt to establish the cause of the profound neurological disease, amyotrophic lateral sclerosis/parkinsonism/dementia, that existed in high frequency amongst the inhabitants of the western Pacific island of Guam.About:
This article is published in Phytochemistry.The article was published on 2017-12-01. It has received 34 citations till now.read more
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Cyanobacterial neurotoxin BMAA and brain pathology in stranded dolphins
David A. Davis,Kiyo Mondo,Erica Stern,Ama K. Annor,Susan J. Murch,Thomas M. Coyne,Larry E. Brand,Misty Niemeyer,Sarah M. Sharp,Walter G. Bradley,Paul Alan Cox,Deborah C. Mash +11 more
TL;DR: The presence of cyanobacterial neurotoxin, β-methylamino-L-alanine (BMAA), and neuropathological changes in the stranded dolphin brain may help to further the understanding of cyanotoxin exposure and its potential impact on human health.
Journal ArticleDOI
Detection of the suspected neurotoxin β-methylamino-l-alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia
Brendan J. Main,Lee C. Bowling,Matthew P. Padula,David P. Bishop,Simon M. Mitrovic,Gilles J. Guillemin,Kenneth J. Rodgers +6 more
TL;DR: The emerging toxin β-methylamino-l-alanine has been linked to the development of a number of neurodegenerative diseases in humans including amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's disease and the presence of these toxins in water used for agriculture raises concerns for public health and food security in Australia.
Marine harmful algal blooms and phycotoxins of concern to Canada
Stephen S. Bates,Daniel G. Beach,Luc A. Comeau,Nicola Haigh,Nancy I. Lewis,Andrea Locke,Jennifer L. Martin,Pearse McCarron,Cynthia H. McKenzie,Christine Michel,Christopher O Miles,Michel Poulin,Michael A. Quilliam,Wade A. Rourke,Michael Scarratt,Michel Starr,Terri Wells +16 more
TL;DR: A review of shellfish toxicity in Canadian waters can be found in this paper, where the authors discuss shellfish poisoning in the Canadian waters and changes in nomenclature of Alexandrium catenella species.
Journal ArticleDOI
Production of β-methylamino-L-alanine (BMAA) and Its Isomers by Freshwater Diatoms.
TL;DR: Results show that BMAA production by diatoms is not confined to marine genera and that the prevalence of these non-protein amino acids in Australian freshwater environments cannot be solely attributed to cyanobacteria.
Journal ArticleDOI
Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases: Dangerous Liaisons
Paola Sini,Thi Bang Chau Dang,Milena Fais,Manuela Galioto,Bachisio Mario Padedda,Antonella Gesuina Laura Lugliè,Ciro Iaccarino,Claudia Crosio +7 more
TL;DR: A review of the most relevant and recent evidence that points at cyanotoxins as environmental triggers in neurodegenerative disease development is presented in this article, where the authors summarize some of the recent evidence pointing at cyanoxins.
References
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Journal ArticleDOI
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants.
TL;DR: The cyclic heptapeptide, microcystin‐LR, inhibits protein phosphatases 1 (PP1) and 2A (PP2A) with K i, values below 0.1 nM, and this results are strikingly similar to those obtained with the tumour promoter okadaic acid.
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Cyanobacterial toxins: risk management for health protection
TL;DR: Key procedures in the risk management of cyanobacterial toxins and cells are reviewed, including derivations of tolerable daily intakes and guideline values with reference to the toxins in drinking water, and guideline levels for toxigenic cyanobacteria in bathing waters.
Journal ArticleDOI
Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin
Peter S. Spencer,Peter B. Nunn,Jacques Hugon,A. C. Ludolph,Stephen M. Ross,Dwijendra N. Roy,Richard C. Robertson +6 more
TL;DR: The hypothesis that cycad exposure plays an important role in the etiology of the Guam disease is supported, as existing epidemiological and animal data support the hypothesis.
Journal ArticleDOI
Diverse taxa of cyanobacteria produce β-N-methylamino-l-alanine, a neurotoxic amino acid
Paul Alan Cox,Sandra Anne Banack,Susan J. Murch,Ulla Rasmussen,Georgia Tien,Robert R. Bidigare,James S. Metcalf,Louise F. Morrison,Geoffrey A. Codd,Birgitta Bergman +9 more
TL;DR: It is reported here that a single neurotoxin, beta-N-methylamino-L-alanine, may be produced by all known groups of cyanobacteria, including cyanobacterial symbionts and free-living cyanob bacteria.
Journal ArticleDOI
Pennate Diatom Nitzschia pungens as the Primary Source of Domoic Acid, a Toxin in Shellfish from Eastern Prince Edward Island, Canada
Stephen S. Bates,C. J. Bird,A. S. W. de Freitas,R. A. Foxall,M. Gilgan,L. A. Hanic,G. R. Johnson,A. W. Mcculloch,P. Odense,R. Pocklington,Michael A. Quilliam,P. G. Sim,J. C. Smith,D. V. Subba Rao,E. C. D. Todd,John A. Walter,Jeffrey L. C. Wright +16 more
TL;DR: An outbreak of food poisoning in Canada during autumn 1987 was traced to cultured blue mussels (Mytilus edulis) from the Cardigan Bay region of eastern Prince Edward Island and represents the first known occurrence of human poisoning by this neurotoxin.