Daniel G. Beach

TL;DR: An in-depth review of the literature surrounding the identification and toxicity of known MCs is conducted to clarify the current state of knowledge on the structural diversity of MCs as a class and the impacts of structure on toxicity, as well as to identify gaps in knowledge that should be addressed in future research.

TL;DR: CyanoMetDB as mentioned in this paper is a large-scale dataset of cyanobacterial secondary metabolites from 850 peer-reviewed articles published between 1967 and 2020, including microcytsins, cyanopeptolins, other depsipeptides, microginins, aeruginosins, cyclamides, cryptophycins, saxitoxins, spumigins, microviridins, and anatoxins among other metabolites.

TL;DR: Using the Suzuki-Miyaura cross-coupling reaction, a number of C(8)-Ar-G-modified oligonucleotides are synthesized (dimers, trimers, decamers, and a 15-mer) using a range of arylboronic acids and are expected to be useful substrates for diagnostic applications and understanding the biological impact of the C( 8)- Ar-G lesion.

TL;DR: DMS separation of BMAA from these isomers was achieved and optimized conditions were used to develop a sensitive and highly selective multidimensional HILIC–DMS–MS/MS method, revealed current technical limitations of DMS for trace quantitation, and practical solutions were implemented.

TL;DR: The current work represents the first successful separation of PST isomers using ion mobility and shows the promise of FAIMS as a tool for analysis of algal biotoxins in complex samples and outlines some critical requirements for its future improvement.