Journal ArticleDOI
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells.
TLDR
Findings indicate that 8-substituted analogues of guanosine and 2'-deoxyguanosine have the potential to terminate leukemia cell proliferation through conversion to end-stage differentiated cells.Abstract:
A variety of 8-substituted guanosine and 2'-deoxyguanosine derivatives were synthesized and tested as inducers of the differentiation of Friend murine erythroleukemia cells in culture. The most active agents in the guanosine series were 8-substituted-N(CH3)2, -NHCH3, -NH2, -OH, and -SO2CH3, which caused 68, 42, 34, 33, and 30% of erythroleukemia cells to attain benzidine positivity, a functional measure of maturation, at concentrations of 5, 1, 0.4, 5, and 5 mM, respectively. The 8-OH derivative of the 2'-deoxyguanosine series produced comparable activity, causing 62% benzidine-positive cells at a level of 0.2 mM. These findings indicate that 8-substituted analogues of guanosine and 2'-deoxyguanosine have the potential to terminate leukemia cell proliferation through conversion to end-stage differentiated cells.read more
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Journal ArticleDOI
NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).cntdot.dA(anti) alignment at lesion site
Michael Kouchakdjian,Veeraiah Bodepudi,Shinya Shibutani,Moises Eisenberg,Francis Johnson,Arthur P. Grollman,Dinshaw J. Patel +6 more
TL;DR: The present study focuses on the major component of the equilibrium that originates in the 6,8-dioxo tautomer of 8-oxo-7H-dG, which contains a centrally located 7-hydro-8-oxodeoxyguanosine residue, a group commonly found in DNA that has been exposed to ionizing radiation or oxidizing free radicals.
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Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α
Robert C. Newton,Carl P. Decicco +1 more
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Substrate specificity and reaction mechanism of murine 8-oxoguanine-DNA glycosylase.
TL;DR: MOgg1 is a DNA glycosylase/AP lyase belonging to the endonuclease III family of DNA repair enzymes, and the proposed mechanism of 8-oxoG excision involves protonation of O8 or the deoxyribose oxygen moiety.
Journal ArticleDOI
1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents
Ish K. Khanna,Richard M. Weier,Yu Yi,Xiangdong Xu,Francis J. Koszyk,Paul W. Collins,Carol M. Koboldt,A. W. Veenhuizen,William E. Perkins,Jacquelen J. Casler,Jaime L. Masferrer,Yan Zhang,S. A. Gregory,Karen Seibert,Peter C. Isakson +14 more
TL;DR: Several orally active diarylimidazoles show no GI toxicity in the rat and mouse up to 200 mpk and a study on the influence of substituents in the imidazole ring established that a CF3 group at position 4 gives the optimum oral activity.
Journal ArticleDOI
Peroxynitrite Mediated Oxidation of Purine Bases of Nucleosides and Isolated DNA
Thierry Douki,Jean Cadet +1 more
TL;DR: Results showed that peroxynitrite exhibits oxidizing properties toward purine moieties both in nucleosides and isolated DNA, and questions the involvement of hydroxyl radicals as the main oxidizing species released by decomposition of per oxynitrous acid.
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