Journal ArticleDOI
A cluster of lysergic acid diethylamide (LSD) poisonings following insufflation of a white powder sold as cocaine.
Darren M. Roberts,Kulanka H. Premachandra,Betty S. Chan,Robin Auld,Thanjira Jiranantakan,Christopher Ewers,Catherine McDonald,Vanessa Shaw,Jared A Brown +8 more
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In this article, the authors discuss the impact of adulteration, substitution or contamination of illicit substances on clinical significance when other illicit substances are included, such circumstances can present as clusters of clusters.Abstract:
Adulteration, substitution or contamination of illicit substances can have clinically significant implications when other illicit substances are included. Such circumstances can present as clusters...read more
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Safer Tripping: Serotonergic Psychedelics and Drug Checking. Submission and Detection Rates, Potential Harms, and Challenges for Drug Analysis
Tim Hirschfeld,Laura Smit-Rigter,Daan van der Gouwe,Simon Reiche,Heino Stöver,Tomislav Majić,Tomislav Majić +6 more
TL;DR: In this article, the authors present the results of a literature search investigating the presence and proportion of serotonergic psychedelics (SPs) in drug checking (DC) samples.
Journal ArticleDOI
Molecular Insights and Clinical Outcomes of Drugs of Abuse Adulteration: New Trends and New Psychoactive Substances
Annagiulia Di Trana,Diletta Berardinelli,E Montanari,Paolo Berretta,Giuseppe Basile,Marilyn A. Huestis,Francesco Paolo Busardò +6 more
TL;DR: A systematic literature search in PubMed and Scopus databases and official international organizations' websites according to PRISMA guidelines was performed as discussed by the authors , where a total of 724 studies were initially screened, with 145 articles from PubMed and 462 from Scopus excluded according to the criteria described in the Method Section.
References
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Journal ArticleDOI
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Franz X. Vollenweider,Margreet F. I. Vollenweider-Scherpenhuyzen,Andreas Bäbler,Helen Vogel,Daniel Hell +4 more
TL;DR: In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotics risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol.
Journal ArticleDOI
The pharmacology of lysergic acid diethylamide: a review.
Torsten Passie,John H. Halpern,John H. Halpern,Dirk O. Stichtenoth,Hinderk M. Emrich,Annelie Hintzen +5 more
TL;DR: There is new interest in LSD as an experimental tool for elucidating neural mechanisms of (states of) consciousness and there are recently discovered treatment options with LSD in cluster headache and with the terminally ill.
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The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation
Katrin H. Preller,Marcus Herdener,Thomas Pokorny,Amanda Planzer,Rainer Kraehenmann,Philipp Stämpfli,Matthias E. Liechti,Erich Seifritz,Franz X. Vollenweider +8 more
TL;DR: Ketanserin inhibited the LSD-induced attribution of personal relevance to previously meaningless stimuli and modulated the processing of meaningful stimuli in cortical midline structures, pointing to the crucial role of the 5-HT2AR subtype and cortical midline regions in the generation and attribution ofpersonal relevance.
Journal ArticleDOI
Adulterants in illicit drugs: a review of empirical evidence
TL;DR: From the reports gathered, adulterants are predominantly substances which are readily available, commonly being caffeine, procaine, paracetamol, and sugars, which are likely to have minimal impact on users' health at low dosages.
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The hallucinogenic world of tryptamines: an updated review
Ana Margarida Araújo,Félix Carvalho,Maria de Lourdes Bastos,Paula Guedes de Pinho,Márcia Carvalho +4 more
TL;DR: A comprehensive update on tryptamine hallucinogens, concerning their historical background, prevalence, patterns of use and legal status, chemistry, toxicokinetics, toxicodynamics and their physiological and toxicological effects on animals and humans is provided.