Journal ArticleDOI
A convenient one-pot conversion of N-protected amino acids and peptides into alcohols
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TLDR
N-Protected amino acids and peptides are converted to alcohols by chemoselective reduction of their corresponding mixed anhydrides with sodium borohydride in tetrahydrofuran with dropwise addition of methanol as mentioned in this paper.Abstract:
N-Protected amino acids and peptides are converted to alcohols by chemoselective reduction of their corresponding mixed anhydrides with sodium borohydride in tetrahydrofuran with dropwise addition of methanolread more
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Journal ArticleDOI
1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis
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Triurethane-Protected Guanidines and Triflyldiurethane-Protected Guanidines: New Reagents for Guanidinylation Reactions
TL;DR: The triflyldiurethane-protected guanidine 3 was utilized to guanidinylate primary and secondary amines under mild conditions with high yield in both solution and on solid phase.
Journal ArticleDOI
Thermoresponsive Dendronized Polymers
TL;DR: In this paper, the efficient synthesis of high molar mass, first- and second-generation (G1) dendronized polymethacrylate derivatives PG1 and PG2, respectively, and their thermoresponsive properties in aqueous solution are described.
Journal ArticleDOI
Thermoresponsive dendronized polymers with tunable lower critical solution temperatures
TL;DR: A series of first and second generation dendronized polymers were synthesized which exhibit fast and sharp phase transitions with negligible hystereses in aqueous solutions and apparent lower critical solution temperatures (LCSTs) in the range of 33-49 degrees C.
Journal ArticleDOI
Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo.
George Kokotos,David A. Six,Vassilios Loukas,Timothy Smith,Violetta Constantinou-Kokotou,Dimitra Hadjipavlou-Litina,Stavroula Kotsovolou,Antonia Chiou,Christopher C. Beltzner,Edward A. Dennis +9 more
TL;DR: This work has further explored this class of inhibitors of Group IVA cytosolic phospholipase A(2) and found that the 2-oxoamide functionality is more potent when it contains a long 2- oxoacyl residue and a free carboxy group.
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