Journal ArticleDOI
A Facile and Stereoselective Synthesis of Arylethers of Vicinal Bromohydrins by Mitsunobu Reaction
TLDR
In this article, a straightforward, high yielding and stereoselective synthesis of 3,4-dihydro-4-aryloxy-3,bromo-2H-1-benzopyrans is reported.About:
This article is published in Synthetic Communications.The article was published on 1994-04-01. It has received 9 citations till now. The article focuses on the topics: Mitsunobu reaction.read more
Citations
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Journal ArticleDOI
Progress in the mitsunobu reaction. a review
TL;DR: A review of progress in the MITSUNOBU this article reaction can be found in this article, with a focus on the MIT SUNOBU reaction and a review of the progress.
Journal ArticleDOI
Asymmetric synthesis of A-240610.0 via a new atropselective approach for axially chiral biaryls with chirality transfer
TL;DR: A new approach for atropselective preparation of axially chiral biaryl was developed, which subsequently led to the successful development of an efficient asymmetric synthesis of A-240610.
Patent
Non-nucleotide composition and method for inhibiting platelet aggregation
James G. Douglass,Robert Plourde,Sammy R. Shaver,Paul S. Watson,José L. Boyer,Jonathan Bryan Decamp,Carl A. Samuelson +6 more
TL;DR: In this paper, the authors proposed a method for preventing or treating diseases or conditions associated with platelet aggregation, which is also directed to a method of treating thrombosis or related disorders, and the method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit Platelet aggregation.
Patent
Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
TL;DR: In this paper, a drug-eluting stent is used to prevent thrombosis and restenosis, and is effective in inhibiting thrombus formation, inhibiting the contraction of vascular smooth muscle cells, and reducing inflammation.
Patent
Non-nucleotide compositions and method for treating pain
Robert Plourde,Sammy R. Shaver,Melwyn Abreo,Lorenzo Josue Alfaro-Lopez,Yangbo Feng,Tatyana V Khasanova,Mark W Holladay,Christopher S. Crean +7 more
TL;DR: In this article, the authors proposed a method of treating pain which consists of administering to a subject a pharmaceutical composition comprising an effective amount of a P2X receptor antagonist, which can also be used in conjunction with other therapeutic agents or adjunctive therapies commonly used to treat pain.
References
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Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
Journal ArticleDOI
The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
TL;DR: In this article, a reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds.
Journal ArticleDOI
Reaktionen mit phosphororganischen Verbindungen. XLI[1]. Neuartige synthetische Aspekte des Systems Triphenylphosphin‐Azodicarbonsäureester‐Hydroxyverbindung
Hans Loibner,Erich Zbiral +1 more
TL;DR: In this paper, a new preparative method using triphenylphosphine-diethylazodicarboxylate-hydroxycompound is presented, in which the anions of phosphonium salts can be used as the nucleophils as is shown by the preparation of the derivatives 2a, 2c, 2f, 2h and 2i from 5α-cholestane-3β-ol.