Journal ArticleDOI
A link between nanoparticles and Parkinson's disease. Which nanoparticles are most harmful?
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TLDR
The toxicity effects of metal and metal oxide NPs have been evaluated in molecular and cellular levels to determine potential of different kinds of NPs in development of Parkinson’s disease.Abstract:
Nowadays, different kinds of nanoparticles (NPs) are produced around the world and used in many fields and products. NPs can enter the body and aggregate in the various organs including brain. They can damage neurons, in particular dopaminergic neurons in the substantia nigra (SN) and striatal neurons which their lesion is associated with Parkinson's disease (PD). So, NPs can have a role in PD induction along with other agents and factors. PD is the second most common neurodegenerative disease in the world, and in patients, its symptoms progressively worsen day by day through different pathways including oxidative stress, neuroinflammation, mitochondrial dysfunction, α-synuclein increasing and aggregation, apoptosis and reduction of tyrosine hydroxylase positive cells. Unfortunately, there is no effective treatment for PD. So, prevention of this disease is very important. On the other hand, without having sufficient information about PD inducers, prevention of this disease would not be possible. Therefore, we need to have sufficient information about things we contact with them in daily life. Since, NPs are widely used in different products especially in consumer products, and they can enter to the brain easily, in this review the toxicity effects of metal and metal oxide NPs have been evaluated in molecular and cellular levels to determine potential of different kinds of NPs in development of PD.read more
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Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson's disease: motor and non-motor outcomes.
Maryam Bigham,Abbas Mohammadipour,Mahmoud Hosseini,Amir Mohammad Malvandi,Alireza Ebrahimzadeh-Bideskan +4 more
TL;DR: In this article, the effects of garlic extract on Parkinson's disease were evaluated on the preclinical model of Wistar rats, and the results revealed that the tyrosine hydroxylase positive cells (TH+) in GE treated groups were significantly higher (p˂0.001) than the lesion group.
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Atrazine neural and reproductive toxicity
Hamid-Reza Sadeghnia,Sara Shahba,Alireza Ebrahimzadeh-Bideskan,Shabnam Mohammadi,Amir Mohammad Malvandi,Abbas Mohammadipour +5 more
TL;DR: Atrazine is one of the common herbicides with an annual usage of 70,000-90,000 tons worldwide as mentioned in this paper and it has a long half-life (>60 days).
Journal ArticleDOI
Roles of the miR-155 in Neuroinflammation and Neurological Disorders: A Potent Biological and Therapeutic Target
Seyed Hamidreza Rastegar-Moghaddam,Alireza Ebrahimzadeh-Bideskan,Sara Shahba,Amir Malvandi,Abbas Mohammadipour +4 more
TL;DR: The molecular pathways which involve MiR-155 as a critical component in the progression of neurological disorders are discussed, representing miR- 155 as a viable therapeutic target.
Journal ArticleDOI
The cytotoxicity of zinc oxide nanoparticles to 3D brain organoids results from excessive intracellular zinc ions and defective autophagy
TL;DR: In this article, the authors used 3D brain organoids that express cortical layer proteins to investigate the mechanisms of ZnO NP-induced neurotoxicity, and they concluded that high concentrations of znO NPs are cytotoxic to 3D-brain organoids via defective autophagy and intracellular accumulation of Zns ions.
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MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders
Seyed Hamidreza Rastegar-Moghaddam,Alireza Ebrahimzadeh-Bideskan,Sara Shahba,Amir Malvandi,Abbas Mohammadipour +4 more
TL;DR: A therapeutic perspective for miR-22 is provided as a new approach in treating neurological disorders, including cerebral ischemia, neurodegenerative diseases, epilepsy, and brain malignancies.
References
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Journal ArticleDOI
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Journal ArticleDOI
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TL;DR: Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting mainly the elderly, although a small proportion of PD patients develop the illness at a much younger age as discussed by the authors.
Journal ArticleDOI
The Interaction of Manganese Nanoparticles with PC-12 Cells Induces Dopamine Depletion
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TL;DR: Results clearly demonstrate that nanoscale manganese can deplete DA, DOPAC, and HVA in a dose-dependent manner and further study is required to evaluate the specific intracellular distribution of Mn-40 nm nanoparticles, metal dissolution rates in cells and cellular matrices, and the propensity of Mn nanoparticles to cross the blood-brain barrier or be selectively uptaken by nasal epithelium.
Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
TL;DR: Evidence from both sporadic and genetic forms of Parkinson's disease that implicate both mitochondria and oxidative stress as central players in disease pathogenesis are reviewed.