David N. Hauser

TL;DR: It is demonstrated that mitochondria are aggregated by p62, following its recruitment by Parkin in a VDAC1-independent manner, and it is suggested that proteins other than p62 are likely required for mitophagy downstream of Parkin substrates other than VD AC1.

TL;DR: The aspects of dopamine as a catecholaminergic neurotransmitter and dopamine signaling pathways elicited through dopamine receptor activation in normal brain function are summarized and the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system are described.

TL;DR: Evidence from both sporadic and genetic forms of Parkinson's disease that implicate both mitochondria and oxidative stress as central players in disease pathogenesis are reviewed.

TL;DR: It is shown, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci, and proposed that three different genes for PD have a common biological function.

TL;DR: A high-resolution transcriptome data set of mouse cerebral cortex at embryonic and adult stages using RNA sequencing (RNA-Seq) is reported, finding many differences in gene expression, splicing and RNA editing between embryonic andadult cerebral cortex.