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Journal ArticleDOI

A Low-Power Blocking-Capacitor-Free Charge-Balanced Electrode-Stimulator Chip With Less Than 6 nA DC Error for 1-mA Full-Scale Stimulation

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TLDR
An electrode-stimulator chip is described that removes the need for large dc blocking capacitors in neural implants by achieving precise charge-balanced stimulation with <6 nA of dc error, well below the industry's safety limit of 25 nA.
Abstract
Large dc blocking capacitors are a bottleneck in reducing the size and cost of neural implants. We describe an electrode-stimulator chip that removes the need for large dc blocking capacitors in neural implants by achieving precise charge-balanced stimulation with <6 nA of dc error. For cochlear implant patients, this is well below the industry's safety limit of 25 nA. Charge balance is achieved by dynamic current balancing to reduce the mismatch between the positive and negative phases of current to 0.4%, followed by a shorting phase of at least 1 ms between current pulses to further reduce the charge error. On +6 and -9 V rails in a 0.7-mum AMI high voltage process, the power consumption of a single channel of this chip is 47 muW when biasing power is shared by 16 channels.

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Citations
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Patent

Implantable Transponder Systems and Methods

TL;DR: In this article, a method and system for providing electrical stimulation to tissue includes implanting one or more battery-free microtransponders having spiral antennas into tissue, where energy is provided wirelessly to the plurality of microtransmoders.
Book

Ultra Low Power Bioelectronics: Fundamentals, Biomedical Applications, and Bio-Inspired Systems

TL;DR: In this paper, the authors lay a foundation in device physics, noise, and feedback systems including nano scales in a highly original fashion, emphasizing intuitive thinking, and identify ten fundamental principles that are common in both biology and electronics, analog and digital design.
Journal ArticleDOI

A Power-Efficient Wireless System With Adaptive Supply Control for Deep Brain Stimulation

TL;DR: A power-efficient wireless stimulating system for a head-mounted deep brain stimulator (DBS) is presented, which increases the stimulation efficiency up to 30% higher than a fixed supply voltage and achieves high AC-DC power conversion efficiency (PCE) through active synchronous switching.
Journal ArticleDOI

A Battery-Powered Activity-Dependent Intracortical Microstimulation IC for Brain-Machine-Brain Interface

TL;DR: An activity-dependent intracortical microstimulation (ICMS) system-on-chip (SoC) that converts extracellular neural spikes recorded from one brain region to electrical stimuli delivered to another brain region in real time in vivo is described.
Journal ArticleDOI

A mm-Sized Wireless Implantable Device for Electrical Stimulation of Peripheral Nerves

TL;DR: Full integration of the implant components, end-to-end in vitro system characterizations, and results for the electrical stimulation of a sciatic nerve, demonstrate the feasibility and efficacy of the proposed stimulator for peripheral nerves.
References
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Book

Analog Integrated Circuit Design

TL;DR: In this paper, the authors present an overview of current mirror and Opamp design and compensation for single-stage Amplifiers and Current Mirrors, as well as a comparison of the two types of Opamps.
Journal ArticleDOI

Chronic electrical stimulation of the auditory nerve at high stimulus rates: A physiological and histopathological study

TL;DR: The results indicated that chronic intracochlear electrical stimulation, using carefully controlled charge-balanced biphasic current pulses at stimulus rates of up to 2000 pps/channel, does not appear to adversely affect residual auditory nerve elements or the cochlea in general.
Journal ArticleDOI

Electrical stimulation of the auditory nerve: direct current measurement in vivo

TL;DR: The authors' model suggests that residual DC is a consequence of Faradaic reactions which allow charge to leak through the electrode tissue interface, and is still present when capacitors are used to achieve charge recovery.
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