A method for separating and concentrating platelets from normal human blood.
Allen H. Minor,Lee Burnett +1 more
TLDR
A met-hod which has been used for the preparation of platelet concentrates from ACD blood is described, which thus involves no significant change in the procedure for blood collection now widely used.About:
This article is published in Blood.The article was published on 1952-07-01 and is currently open access. It has received 47 citations till now. The article focuses on the topics: Whole blood & Thrombocytopenic purpura.read more
Citations
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Journal ArticleDOI
Immunologic mechanisms in idiopathic and neonatal thrombocytopenic purpura
William J. Harrington,Charles C. Sprague,Virginia Minnich,Carl V. Moore,Robert C. Aulvin,Reubenia Dubach +5 more
TL;DR: The mechanisms responsible for the low platelet count in idiopathic thrombocytopenic purpura are not well understood despite the careful studies by many competent investigators.
Journal ArticleDOI
Transfusions of fresh platelet concentrates to patients with secondary thrombocytopenia.
TL;DR: Clinical studies comparable to those in animals have not been possible, however, because of the variations in bleeding manifestations of untreated thrombocytopenic patients and the difficulties encountered in carrying out well controlled studies during medical or surgical emergencies.
Journal ArticleDOI
Collection, preservation and transfusion of platelets; with special reference to the factors affecting the survival rate and the clinical effectiveness of transfused platelets.
Mario Stefanini,William Dameshek +1 more
TL;DR: It is theoretically possible that, if a drastic but temporary depression of abnormal cell production could be obtained by various chemotherapeutic agents even at the expense of severe bone-marrow injury, lengthy remissions would occur in certain types of cancer.
Journal Article
ABO groups in blood platelets
J. Gurevitch,D. Nelken +1 more
TL;DR: It is found that suspensions of blood platelets in normal saline are agglutinated by A- B- and O-sera, just as these sera agglUTinate red blood cells of the corresponding blood group, and it is thus possible to establish four blood groups for the blood Platelets, similar to the blood groups in erythrocytes.
Book ChapterDOI
The Isolation of Subcellular Components
TL;DR: This chapter discusses the isolation of subcellular components; in many cases, isolated cell structures can be tested for their retention of function, that is, for their capacity to mediate or carry out complex synthetic reactions in vitro.
References
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Sustained hyperlipemia induced in rabbits by means of intravenously injected surface-active agents
TL;DR: The intravenous injection of the surface-active agents Tween 80 and Triton A20 into rabbits fed a normal diet resulted in marked and sustained elevations of the cholesterol, phospholipid, and total lipid content of their blood.
Journal ArticleDOI
Separation, concentration, and transfusion of platelets.
TL;DR: A simple method is presented for the efficient separation and concentration of platelets from human, dog, and guinea pig blood in quantities sufficient for transfusion and depends upon the use of Sequesterene Na2 as an anticoagulant.
Journal ArticleDOI
Studies on platelets. II. The effect of transfusion of platelet-rich polycythemic blood on the platelets and hemostatic function in "idiopathic" and "secondary" thrombocytopenic purpura.
TL;DR: The prompt disappearance of injected platelets from the circulation of patients with "idiopathic" thrombocytopenia suggests a humoral destructive mechanism, which is not present in the "secondary" or "amegakaryocytic" cases and suggests that polycythemic blood may contain a stimulatory principle which can determine or accelerate a spontaneous remission.
Journal ArticleDOI
Thrombopathic thrombocytopenia; successful transfusion of blood platelets.
TL;DR: A patient’s platelets were not only reduced in number but were morphologically abnormal and physiologically defective, and possible mechanisms leading to their relatively low recovery are discussed.
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Separation, concentration, and transfusion of platelets.
Collection, preservation and transfusion of platelets; with special reference to the factors affecting the survival rate and the clinical effectiveness of transfused platelets.
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