Journal ArticleDOI
A model for ageing.
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TLDR
The model takes into account two main characteristics of ageing: deterioration of adaptability of an organism to environment after maturity and determination of life span of a species.About:
This article is published in Journal of Theoretical Biology.The article was published on 1975-01-01. It has received 91 citations till now.read more
Citations
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Invited review: Theories of aging.
TL;DR: The presence of several trajectories of the life span, from incidence of disease and disability to absence of pathology and persistence of function, suggest that it is possible to experimentally prolong functional plasticity and life span.
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The aging process and potential interventions to extend life expectancy.
TL;DR: The present review provides an overlook of the most commonly accepted theories of aging, providing current evidence of those interventions aimed at modifying the aging process.
Journal ArticleDOI
Protein synthesis and degradation during aging and senescence
TL;DR: The published results on protein synthesis during aging are contradictory and possible sources of error and variability include an insufficient number of different animal ages used, use of whole organs that are cytologically highly heterogeneous, and inadequate methodology for measurement of in vivo rates of protein synthesis.
References
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Journal ArticleDOI
Gene Regulation for Higher Cells: A Theory
Roy J. Britten,Eric H. Davidson +1 more
TL;DR: Direct support for the idea that regulation of gene activity underlies cell differentiation comes from evidence that much of the genome in higher cell types is inactive and that different ribonucleic acids are synthesized in different cell types.
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Ageing of Clones of Mammalian Cells
TL;DR: The chief purpose of this article is to review some recent work on the ageing of mammalian cells and to comment on the theoretical interpretation of the experimental findings.
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Altered enzymes in ageing human fibroblasts.
Robin Holliday,G. M. Tarrant +1 more
TL;DR: Observations support Orgel's “error catastrophe” theory of ageing by showing that the RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme.