Journal ArticleDOI
Gene Regulation for Higher Cells: A Theory
Roy J. Britten,Eric H. Davidson +1 more
TLDR
Direct support for the idea that regulation of gene activity underlies cell differentiation comes from evidence that much of the genome in higher cell types is inactive and that different ribonucleic acids are synthesized in different cell types.Abstract:
Cell differentiation is based almost certainly on the regulation of gene activity, so that for each state of differentiation a certain set of genes is active in transcription and other genes are inactive. The establishment of this concept (1) has depended on evidence
indicating that the cells of an organism generally contain identical genomes (2). Direct support for the idea that regulation of gene activity underlies cell differentiation
comes from evidence that much of the genome in higher cell
types is inactive (3) and that different ribonucleic acids (RNA) are synthesized in different cell types (4).read more
Citations
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Journal ArticleDOI
Genome Regulation by Long Noncoding RNAs
John L. Rinn,Howard Y. Chang +1 more
TL;DR: Long noncoding RNAs (lncRNAs) as discussed by the authors form extensive networks of ribonucleoprotein (RNP) complexes with numerous chromatin regulators and then target these enzymatic activities to appropriate locations in the genome.
Journal ArticleDOI
RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription
Philipp Kapranov,Jill Cheng,Sujit Dike,David A. Nix,Radharani Duttagupta,Aarron T. Willingham,Peter F. Stadler,Jana Hertel,Jörg Hackermüller,Ivo L. Hofacker,Ian Bell,Evelyn Cheung,Jorg Drenkow,Erica Dumais,Sandeep Patel,Gregg Helt,Madhavan Ganesh,Srinka Ghosh,Antonio Piccolboni,Victor Sementchenko,Hari Tammana,Thomas R. Gingeras +21 more
TL;DR: Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes and support a highly interleaved organization of the human transcriptome.
Journal ArticleDOI
Selfish DNA: the ultimate parasite
Leslie E. Orgel,Francis Crick +1 more
TL;DR: The DNA of higher organisms usually falls into two classes, one specific and the other comparatively nonspecific, and it seems plausible that most of the latter originated by the spreading of sequences which had little or no effect on the phenotype.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
References
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Journal ArticleDOI
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François Jacob,Jacques Monod +1 more
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J Paul,R.Stewart Gilmour +1 more
TL;DR: It is concluded that histones can mask DNA in chromatin and prevent it from acting as a template, but this effect is nonspecific.
Journal ArticleDOI
The desoxyribonucleic acid content of animal cells and its evolutionary significance.
Alfred E. Mirsky,Hans Ris +1 more
TL;DR: The values of DNA per cell in lung fishes, amphibians, reptiles, and birds suggest that in the evolution of these vertebrates there has been a decline in DNA content per cell.
Journal ArticleDOI
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