Journal ArticleDOI
A model of cerebral circulation disorders created by staged ligation of the common carotid arteries.
I. V. Fateev,V. N. Bykov,S. V. Chepur,L. A. Pokrovskaya,N. I. Shemeleva,O. O. Vladimirova,I. I. Alekseeva +6 more
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TLDR
A model of brain ischemia induced by staged ligation of the left and right common carotid arteries has been developed in experiments on rats and is recommended for evaluation of the efficiency of drugs of various pharmacological groups.Abstract:
A model of brain ischemia induced by staged ligation of the left and right common carotid arteries has been developed in experiments on rats. The use to this model led to reduction of animal mortality. On days 2-5 after the second ligature, the animals lost weight, the level of their CNS vulnerability increased, the volume of perceived information reduced, adaptation to environmental conditions and reproduction of conditioned reflexes were disordered. Focal and diffuse destructive changes in the nerve and glia cells were found in the cerebral cortex, hippocampus, and thalamic nuclei. The severity of disorders in the blood supply to the brain depended on the interval between ligation of the carotid arteries. This recommends this model for evaluation of the efficiency of drugs of various pharmacological groups.read more
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Neuroprotection of Gueichih-Fuling-Wan on cerebral ischemia/ reperfusion injury in streptozotocin-induced hyperglycemic rats via the inhibition of the cellular apoptosis pathway and neuroinflammation.
Yuh-Fung Chen,Kuo-Jen Wu,Wei-Shih Huang,Yow-Wen Hsieh,Yu-Wen Wang,Huei-Yann Tsai,Ming-Ming Lee +6 more
TL;DR: GFW has good bioactivities to protect cerebral I/R injury in hyperglycemic rats, which might be due to inhibition of cellular apoptosis and neuroinflammation.
Journal ArticleDOI
Pipoxolan Ameliorates Cerebral Ischemia via Inhibition of Neuronal Apoptosis and Intimal Hyperplasia through Attenuation of VSMC Migration and Modulation of Matrix Metalloproteinase-2/9 and Ras/MEK/ERK Signaling Pathways
TL;DR: PIPO is protective in models of ischemia/reperfusion-induced cerebral infarction, carotid artery ligation-induced intimal hyperplasia and VSMC migration both in vivo and in vitro.
Journal ArticleDOI
Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats.
Shunrou Fujiwara,Shunrou Fujiwara,Yuki Mori,Daniela Martinez de la Mora,Yosuke Akamatsu,Kenji Yoshida,Yuji Shibata,Tomoyuki Masuda,Kuniaki Ogasawara,Yoshichika Yoshioka +9 more
TL;DR: All three models were able to identify cerebral ischemic change and damage as IVIM parameter change among three phases and the kurtosis model could identify the parameter changes in more regions than the other two models.
References
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Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data
Alan D. Lopez,Colin Mathers,Majid Ezzati,Dean T. Jamison,Dean T. Jamison,Christopher J L Murray +5 more
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Animal Models of Ischemic Stroke. Part Two: Modeling Cerebral Ischemia
TL;DR: In the first part of the review animal models developed for studying stroke related risk factors are described while this section discusses specific models that have been created for mimicking different types of stroke, focal and global ischemia in an experimental setup.
Journal ArticleDOI
Laser-Doppler Scanning of Local Cerebral Blood Flow and Reserve Capacity and Testing of Motor and Memory Functions in a Chronic 2-Vessel Occlusion Model in Rats
TL;DR: Memory retention function remained impaired after BCO, as did the acetazolamide response, which correlated with motor score and was inversely related to maze exploration time, in a pathophysiological setting similar to hemodynamic insufficiency in humans.
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Stroke treatment--light at the end of the tunnel?
TL;DR: Despite the high-profile failures of two more stroke drugs in late-stage trials, biotech firms are persevering with new approaches and treatments.
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Expression changes of the mRNA of Alzheimer's disease related factors in the permanent ischemic rat brain.
Michihisa Tohda,Prawpan Suwanakitch,Rattima Jeenapongsa,Hisae Hayashi,Hiroshi Watanabe,Kinzo Matsumoto +5 more
TL;DR: The rat with permanent occlusion of the bilateral common carotid arteries (2VO) is useful model for the study of dementia and results suggest that alpha7NicR expression was enhanced at early stage of brain ischemia.
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