D
Dirk M. Hermann
Researcher at University of Duisburg-Essen
Publications - 386
Citations - 15491
Dirk M. Hermann is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Stroke & Neuroprotection. The author has an hindex of 62, co-authored 334 publications receiving 12582 citations. Previous affiliations of Dirk M. Hermann include University of Zurich & University of Giessen.
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Journal ArticleDOI
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper
Thomas Lener,Mario Gimona,Ludwig Aigner,Verena Börger,Edit I. Buzás,Giovanni Camussi,Nathalie Chaput,Devasis Chatterjee,Felipe A. Court,Hernando A. del Portillo,Lorraine O'Driscoll,Stefano Fais,Juan M. Falcón-Pérez,Ursula Felderhoff-Mueser,Lorenzo Fraile,Yong Song Gho,André Görgens,Ramesh C. Gupta,An Hendrix,Dirk M. Hermann,Andrew F. Hill,Fred H. Hochberg,Peter A. Horn,Dominique P.V. de Kleijn,Lambros Kordelas,Boris W. Kramer,Eva-Maria Krämer-Albers,Sandra Laner-Plamberger,Saara Laitinen,Tommaso Leonardi,Magdalena J. Lorenowicz,Sai Kiang Lim,Jan Lötvall,Casey A. Maguire,Antonio Marcilla,Irina Nazarenko,Takahiro Ochiya,Tushar Patel,Shona Pedersen,Gabriella Pocsfalvi,Stefano Pluchino,Peter J. Quesenberry,Ilona G. Reischl,Francisco J. Rivera,Ralf Sanzenbacher,Katharina Schallmoser,Ineke Slaper-Cortenbach,Dirk Strunk,Torsten Tonn,Pieter Vader,Pieter Vader,Bas W.M. van Balkom,Marca H. M. Wauben,Samir El Andaloussi,Samir El Andaloussi,Clotilde Théry,Eva Rohde,Bernd Giebel +57 more
TL;DR: In this paper, the authors summarize recent developments and the current knowledge of extracellular vesicles (EVs) and discuss safety and regulatory requirements that must be considered for pharmaceutical manufacturing and clinical application.
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Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
Thorsten R. Doeppner,Josephine Herz,André Görgens,Jana Schlechter,Anna-Kristin Ludwig,Stefan Radtke,Kyra de Miroschedji,Peter A. Horn,Bernd Giebel,Dirk M. Hermann +9 more
TL;DR: Improved neurological impairment and long‐term neuroprotection associated with enhanced angioneurogenesis were noticed in stroke mice receiving EVs from two different bone marrow‐derived MSC lineages, providing clinically relevant evidence warranting rapid proof‐of‐concept studies in stroke patients.
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Post-stroke dementia - a comprehensive review
Milija Mijajlovic,Aleksandra M. Pavlović,Michael Brainin,Wolf-Dieter Heiss,Terence J. Quinn,Hege Ihle-Hansen,Dirk M. Hermann,Einor Ben Assayag,Edo Richard,Alexander Thiel,Efrat Kliper,Yong Il Shin,Yun Hee Kim,Seong Hye Choi,San Jung,Yeong Bae Lee,Osman Sinanović,Deborah Levine,Ilana Schlesinger,Ilana Schlesinger,Gillian Mead,Vuk Milošević,Didier Leys,Guri Hagberg,Marie Helene Ursin,Yvonne Teuschl,S. V. Prokopenko,Elena Mozheyko,Anna Bezdenezhnykh,Karl Matz,Vuk Aleksić,Dafin F. Muresanu,Amos D. Korczyn,Natan M. Bornstein +33 more
TL;DR: PSD is proposed as a label for any dementia following stroke in temporal relation and no specific biomarkers have been proven to robustly discriminate vulnerable patients (‘at risk brains’) from those with better prognosis or to discriminate Alzheimer’s disease dementia from PSD.
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Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms
Marco Bacigaluppi,Stefano Pluchino,Luca Peruzzotti Jametti,Ertugrul Kilic,Ulkan Kilic,Giuliana Salani,Elena Brambilla,Mark J. West,Giancarlo Comi,Gianvito Martino,Dirk M. Hermann,Dirk M. Hermann +11 more
TL;DR: The effects of a delayed transplantation of adult syngenic NPCs--injected intravenously 72 h after transient middle cerebral artery occlusion--on neurological recovery, histopathology and gene expression and Histopathological analysis revealed a hitherto unreported very delayed neuroprotective effect of NPCs.
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Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation
TL;DR: Suggestions for the translation of restorative therapies from the laboratory to the clinic are provided, mindful of the complexity of the systems involved and the possible risks.