Journal ArticleDOI
A multicenter study of levonorgestrel-estradiol contraceptive vaginal rings. I-Use effectiveness. An international comparative trial.
Irving Sivin,Daniel R. Mishell,Arne Victor,Soledad Diaz,Francisco Alvarez-Sanchez,Niels Christian Nielsen,Oladele Akinla,Tapani Pyorala,Elsimar Metzker Coutinho,Anibal Faundes,Subir Roy,Paul F. Brenner,Tom Ahren,Margarita Pavez,Vivian Brache,O.F. Giwa-Osagie,Margaret O. Fasan,Belinha Zausner-Guelman,Elias Darze,Jose Carlos Gama daSilva,Juan Diaz,Theodore M. Jackanicz,Janet Stern,Harold A. Nash +23 more
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TLDR
These trials indicate that CVRs of this design are as effective and have continuation rates equal to and possibly superior to Nordette under the same study conditions.About:
This article is published in Contraception.The article was published on 1981-10-01. It has received 66 citations till now. The article focuses on the topics: Levonorgestrel & Population.read more
Citations
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Journal ArticleDOI
Why consider vaginal drug administration
Nancy J Alexander,Nancy J Alexander,Edward Baker,Marc Carel John Kaptein,Ulrich Karck,Leslie W. Miller,Edio Zampaglione +6 more
TL;DR: The safety and efficacy of vaginal administration have been well established and the vaginal route of drug delivery is acceptable and may even be a preferable route of administration for many drugs, particularly hormones, whether for contraception or postmenopausal estrogen therapy.
Journal ArticleDOI
Microdose intravaginal levonorgestrel contraception: A multicentre clinical trial
Suporn Koetsawang,Ji Gao,U. Krishna,A. Cuadros,G.I. Dhall,R. Wyss,J.Rodriquez la Puenta,Amaury Teixeira Leite Andrade,Talat Khan,E.S. Kononova,J.P. Lawson,U. Parekh,M. Elstein,V. Hingorani,Na-ning Wang,Zhong-beng Yao,Britt-Marie Landgren,R. Boukhris,Li-lan Lo,S. Boccard,David Machin,A. Pinol,P.J. Rowe +22 more
TL;DR: It is concluded that the WHO intravaginal ring releasing an average of 20 micrograms of levonorgestrel per 24 hours is an effective method of contraception for at least one year of use.
Journal ArticleDOI
Contraceptive vaginal rings: a review
Vivian Brache,Anibal Faundes +1 more
TL;DR: Evidence that CVRs are safe, effective and highly acceptable to women is provided and there is no doubt thatCVRs offer a new, effective contraceptive option to women, expanding their options of hormonal contraception.
Journal ArticleDOI
Contraceptive vaginal rings releasing Nestorone and ethinylestradiol: a 1-year dose-finding trial.
Irving Sivin,Daniel R. Mishell,Francisco J. Alvarez,Vivian Brache,Kaisa Elomaa,Pekka Lahteenmaki,Rebeca Massai,P. Miranda,Horacio B. Croxatto,Catherine Dean,Margaret Small,Harold A. Nash,Theodore M. Jackanicz +12 more
TL;DR: Clinical performance and adverse event profiles indicate that each of these 1-year NES/EE rings, used on a 21-day-in and 7- day-out regimen, provided women effective, acceptable and safe long-acting contraception under their own control.
Journal ArticleDOI
Current status of contraceptive vaginal rings.
TL;DR: The main advantages of CVRs are their effectiveness, ease of use without the need of remembering a daily routine, user ability to control initiation and discontinuation, nearly constant release rate allowing for lower doses, greater bioavailability and good cycle control with the combined ring, in comparison with oral contraceptives.
References
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Journal ArticleDOI
Clinical performance and endocrine profiles with contraceptive vaginal rings containing a combination of estradiol and d-norgestrel.
TL;DR: This method has the advantage of inhibition of ovulation and good control of bleeding without the disadvantage of producing some adverse metabolic effects.
Journal ArticleDOI
A multicenter study of levonorgestrel-estradiol contraceptive vaginal rings. II-Subjective and objective measures of effects. An international comparative trial.
Irving Sivin,Daniel R. Mishell,Arne Victor,Soledad Diaz,Francisco Alvarez-Sanchez,Niels Christian Nielsen,Oladele Akinla,Tapani Pyorala,Elsimar Metzker Coutinho,Anibal Faundes,Subir Roy,Paul F. Brenner,Tom Ahren,Margarita Pavez,Vivian Brache,O.F. Giwa-Osagie,Margaret O. Fasan,Belinha Zausner-Guelman,Elias Darze,Jose Carlos Gama daSilva,Juan Diaz,Theodore M. Jackanicz,Janet Stern,Harold A. Nash +23 more
TL;DR: The incidence of spontaneous complaints was similar among users of the 2 different-sized rings and of the pill, and side effects of Nordette, the oral contraceptive, were similar.
Journal ArticleDOI
The effect on lipids and lipoproteins of a contraceptive vaginal ring containing levonorgestrel and estradiol
TL;DR: The potential reduction in predicted coronary risk with the use of the CVR suggested by a reduction in cholesterol was counterbalanced by a Reduction in HDL-C and increases in the cholesterol/HDL-C, LDL/HDC and LDL/ HDL ratios.
Journal ArticleDOI
Lipoprotein patterns in women in santo domingo using a levonorgestrel/estradiol contraceptive ring
Dale N. Robertson,F. Alvarez,Irving Sivin,Vivian Brache,Janet Stern,Patricia Leon,Anibal Faundes +6 more
TL;DR: Ten healthy, normally menstruating women attending a family planning clinic in Santo Domingo Participated in a study to determine the effects on plasma lipid levels of levonorgestrel and estradiol released from a contraceptive ring.
Journal ArticleDOI
Serum lipoprotein and apolipoprotein changes during treatment with a contraceptive vaginal ring containing levonorgestrel and estradiol.
TL;DR: The low basal level of LDL and its further decrement during treatment alleviate the supposedly unfavorable effect of HDL reduction from the atherogenic point of view.
Related Papers (5)
Microdose intravaginal levonorgestrel contraception: A multicentre clinical trial
Suporn Koetsawang,Ji Gao,U. Krishna,A. Cuadros,G.I. Dhall,R. Wyss,J.Rodriquez la Puenta,Amaury Teixeira Leite Andrade,Talat Khan,E.S. Kononova,J.P. Lawson,U. Parekh,M. Elstein,V. Hingorani,Na-ning Wang,Zhong-beng Yao,Britt-Marie Landgren,R. Boukhris,Li-lan Lo,S. Boccard,David Machin,A. Pinol,P.J. Rowe +22 more
Contraceptive effect of varying dosages of progestogen in silastic vaginal rings
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