Journal ArticleDOI
A multifunctional integrated simultaneously online screening microfluidic biochip for the examination of “efficacy-toxicity” and compatibility of medicine
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TLDR
The novel microfluidic chip-based multifunctional integrated system congregated the virtues of high throughput, rapid, sensitive, specific, cost-effective, and similar to the physical environment of the human body, which was especially suitable for the medicine efficacy-toxicity and compatibility evaluation.About:
This article is published in Chinese Chemical Letters.The article was published on 2019-02-01. It has received 10 citations till now. The article focuses on the topics: Biochip.read more
Citations
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Millifluidics, microfluidics, and nanofluidics: manipulating fluids at varying length scales
L. Chen,L. Chen,Chenjing Yang,Yao Xiao,Xiaoxiao Yan,L. Hu,M. Eggersdorfer,Dong Chen,D.A. Weitz,F. Ye +9 more
TL;DR: In this paper, the major physics associated with flow properties and interactions of millifluidics, microfluidics and nanofluids are discussed in detail, especially the differences arising from different length scales.
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Application of adaptive pressure-driven microfluidic chip in thyroid function measurement
TL;DR: A microfluidic chip based on a polystyrene polymer substrate provides a new method for the determination of thyroid function and lays a foundation for subsequent clinical application.
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An integrated microfluidic concentration gradient generator for mechanical stimulation and drug delivery
TL;DR: An integrated concentration gradient generator capable of providing cell monolayers with mechanical stimuli and its design, fabrication, and quantification procedures are demonstrated and the biocompatibility of the proposed device is investigated by dynamic culturing of human lung cancer cells on the chip.
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Recent Progress in Microneedles‐Mediated Diagnosis, Therapy, and Theranostic Systems
Jian Yang,Jingbo Yang,Xia Gong,Ying Zheng,Shengzhu Yi,Yan Li Cheng,Yanjun Li,Bin Liu,Xi Xie,Changqing Yi,Lelun Jiang +10 more
TL;DR: Taken together, microneedle‐based systems are promising as the new avenue for diagnosis, therapy, and disease‐specific closed‐loop theranostic applications.
Journal ArticleDOI
Ionic current rectification in asymmetric nanofluidic devices
TL;DR: In this article, the ICR property in nanofluidics as well as the underlying mechanism is demonstrated, and the influencing factors concerning to the ionic current rectification (ICR) are systematically summarized.
References
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Journal ArticleDOI
Microfluidic organs-on-chips
TL;DR: A microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology has great potential to advance the study of tissue development, organ physiology and disease etiology.
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Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide
TL;DR: It is concluded that IEC limit dysregulated LPS signaling by down-regulating expression of MD-2 and TLR4 and the remainder of the intracellular L PS signaling pathway is functionally intact.
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Microfluidic Organ-on-a-Chip Models of Human Intestine.
Amir Bein,Woojung Shin,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Min Hee Park,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Alessio Tovaglieri,Alessio Tovaglieri,Angeliki Chalkiadaki,Hyun-Jung Kim,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +13 more
TL;DR: How microfluidic Intestine Chips offer new capabilities not possible with conventional culture systems or organoid cultures, including the ability to analyze contributions of individual cellular, chemical, and physical control parameters one-at-a-time is described.
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Why microfluidics? Merits and trends in chemical synthesis
TL;DR: This review focuses on the improved performance of microreactors in handling various situations, and outline the trend of microfluidic synthesis (microsynthesis, μSyn) from simple microreactor to integrated microsystems, to provide strategic guidance for the rational design, fabrication, and integration of microdevices for synthetic use.
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Combining Multiplex SERS Nanovectors and Multivariate Analysis for In Situ Profiling of Circulating Tumor Cell Phenotype Using a Microfluidic Chip.
TL;DR: The results demonstrate that this platform can identify cancer subtypes with the spectral information correlated to the clinically relevant surface receptors, which holds great potential for clinical cancer diagnosis and precision medicine.