Journal ArticleDOI
A novel three-component one-pot synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines using microwave heating in the solid state
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TLDR
Microwave-assisted three-component cyclocondensation of barbituric acids, benzaldehyde and alkyl nitriles was shown to yield pyrano[2,3-d]pyrimidines.About:
This article is published in Tetrahedron Letters.The article was published on 2003-11-03. It has received 144 citations till now.read more
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Utilisation of 1,3‐Dicarbonyl Derivatives in Multicomponent Reactions
TL;DR: In this article, an overview of the potential of 1,3-dicarbonyl derivatives for the selective construction of highly functionalised small organic molecules of high synthetic and biological value is presented.
Journal ArticleDOI
Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis
TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.
Journal ArticleDOI
Metal-Free Multicomponent Syntheses of Pyridines
Patent
Dipeptidyl peptidase inhibitors
Jun Feng,II Stephen L. Escondido Gwaltney,Stephen W. Kaldor,Jeffrey A. Stafford,Michael B. Wallace,Zhiyuan Zhang +5 more
TL;DR: In this paper, pharmaceuticals, kits and methods for use with DPP-IV and other S9 proteases that comprise a compound comprising of CO, SO, SO 2, and C═NR 9 are described.
Journal ArticleDOI
Uncatalysed Knoevenagel condensation in aqueous medium at room temperature
Mohit L. Deb,Pulak J. Bhuyan +1 more
TL;DR: In this article, the condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like malononitrile, e.g., barbituric acids, Meldrum's acid, dimedone and pyrazolone is described.
References
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Multiple-Component Condensation Strategies for Combinatorial Library Synthesis
TL;DR: This Account focuses on multiple-component condensations (MCCs) as one subset of strategies for the generation of compound libraries, and it is instructive to contrast this approach with linear synthesis to highlight the differences in methods, potential library size, and output format.
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Ueber die künstliche Bildung der Milchsäure und einen neuen, dem Glycocoll homologen Körper;
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Discovery of New Multi Component Reactions with Combinatorial Methods
TL;DR: This "combinatorial reaction finding" provides also a powerful tool to the understanding of the rules of organic chemistry, especially structure-reactivity relationships.
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Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine
TL;DR: In this paper, the synthesis of 2,4-diamino-7,8-dihydro-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine (BW301U, 7) by a route that has general applicability to the preparation of many 6-(substituted benzyl) 5-methyl pyridines is described.
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A novel microwave-mediated one-pot synthesis of indolizines via a three-component reaction.
TL;DR: The microwave-mediated three-component reaction of acyl bromide, pyridine, and acetylene is catalyzed by basic alumina to give corresponding indolizines in excellent yields in a one-pot reaction.