A pilot placebo-controlled study of fluvoxamine for pathological gambling.
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Fluvoxamine may be a useful treatment for certain subgroups of patients with pathological gambling, and several methodological recommendations are made for future pharmacological trials of pathological gambling.Abstract:
The objective of this study was to evaluate the efficacy of fluvoxamine in the treatment of pathological gambling. Thirty-two patients were treated for 6 months in a double-blind, placebo-controlled study of fluvoxamine 200 mg/day. Outcome measures included reduction in money and time spent gambling per week. Longitudinal mixed effects models and completers analyses were used for estimation and hypothesis testing. Fluvoxamine was not statistically significantly different from placebo in the overall sample. However, fluvoxamine was statistically significantly superior to placebo in males and in younger patients. The power of the study was limited by the high (59%) placebo-response rate. Fluvoxamine may be a useful treatment for certain subgroups of patients with pathological gambling. Several methodological recommendations are made for future pharmacological trials of pathological gambling.read more
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Pathological Gambling: Etiology, Comorbidity, and Treatment
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Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity
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Neurobiology of addiction. An integrative review.
TL;DR: An integrative review of the literature that addresses the neurobiology of addiction is presented, directed toward identifying candidate neurochemical substrates for the impairments in motivation-reward, affect regulation, and behavioral inhibition that could contribute to an addictive process.
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TL;DR: Membership in youth, treatment, or prison population segments is significantly associated with experiencing gambling-related disorders and understanding subclinical gamblers provides a meaningful opportunity to lower the public health burden associated with gambling disorders.
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Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling
TL;DR: Results suggest that naltrexone is effective in reducing the symptoms of pathologic gambling.