Journal ArticleDOI
A pilot study of the feasibility of long-term human bone balance during perimenopause using a 41Ca tracer
TLDR
A pilot long-term feasibility study of bone health is explored by measuring the 41 Ca trace element in urine for six years from premenopausal to later perimenopausal phases in one midlife woman and measuring bone mineral density in parallel.Abstract:
The mechanisms governing calcium fluxes during bone remodeling processes in perimenopausal women are poorly known. Despite higher, albeit erratic, estradiol levels in perimenopause, spine bone loss is greater than during the first five years past the final menstrual flow when estradiol becomes low. Understanding changes during this dynamic transition are important to prevent fragility fractures in midlife and older women. The exploration of long-lived 41 Ca ( T 1/2 = 1.04 × 10 5 yrs) tracer measurements using accelerator mass spectrometry (AMS) leads to the possibility of monitoring bone remodeling balance. With this new technology, we explored a pilot long-term feasibility study of bone health by measuring the 41 Ca trace element in urine for six years from premenopausal to later perimenopausal phases in one midlife woman. We measured bone mineral density in parallel.read more
Citations
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Journal ArticleDOI
The Influence of Therapeutic Radiation on the Patterns of Bone Marrow in Ovary-Intact and Ovariectomized Mice
Susanta K. Hui,Leslie C. Sharkey,Louis S. Kidder,Yan Zhang,Greg Fairchild,Kayti Coghill,Cory J. Xian,Douglas Yee +7 more
TL;DR: Ovariectomy prior to delivery of a clinically-relevant focal radiation exposure in mice, exacerbated post-radiation adipose accumulation in the marrow space but blunted bone loss and hematopoietic suppression in the normally coupled homeostatic relationship between the bone and marrow domains, OVX appears to alter feedback mechanisms.
Journal ArticleDOI
Development of Accelerator Mass Spectrometry and Its Applications
TL;DR: In this paper, a brief description of the basic principles of AMS and then a review of recent technical developments are presented. And the trends and challenges of AMs development are briefly discussed.
Journal ArticleDOI
Skeletal Remodeling Following Clinically Relevant Radiation-Induced Bone Damage Treated with Zoledronic Acid
Susanta K. Hui,Gregory R. Fairchild,Gregory R. Fairchild,Louis S. Kidder,Manju Sharma,Maryka Bhattacharya,Scott A. Jackson,Chap T. Le,Douglas Yee +8 more
TL;DR: 45Ca assay is useful to monitor the time course of bone mineral remodeling after an antiresorptive intervention in irradiated mice, providing a basis to investigate bone effects of cancer therapy protocols.
Journal ArticleDOI
The influence of therapeutic radiation on the patterns of bone remodeling in ovary-intact and ovariectomized mice.
Susanta K. Hui,Gregory R. Fairchild,Gregory R. Fairchild,Louis S. Kidder,Manju Sharma,Maryka Bhattacharya,Scott A. Jackson,Chap T. Le,Anna Petryk,Mohammad Saiful Islam,Douglas Yee +10 more
TL;DR: The 45Ca assay effectively indicates the onset and rate of systemic bone mineral remodeling, providing real-time assessment of changes in bone histomorphometric parameters.
Journal ArticleDOI
Calcium-41: a technology for monitoring changes in bone mineral.
Connie M. Weaver,Berdine R. Martin,George S. Jackson,George P. McCabe,Munro Peacock,Meryl E. Wastney +5 more
TL;DR: The rare, long-lived radiotracer, 41Ca, measured by accelerator mass spectrometry in the urine or serum following incorporation into the bone provides an ultra-sensitive tool to assess changes in bone calcium balance in response to an intervention.
References
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Journal ArticleDOI
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Journal Article
Menopausal changes in calcium balance performance.
TL;DR: In this article, the authors found a statistically significant positive correlation between calcium balance and both calcium intake and calcium absorption, and concluded that there is a specific, estrogen-related shift in calcium performance across menopause and that the reason for the positive effect of estrogen on balance and intake requirement is a combination of enhancement of intestinal absorption efficiency and improved renal calcium conservation.
Journal ArticleDOI
Spinal Bone Loss and Ovulatory Disturbances
TL;DR: The density of cancellous spinal bone from the 12th thoracic vertebra to the 3rd lumbar vertebra was measured by quantitative computed tomography on two occasions one year apart in 66 premenopausal women 21 to 42 years of age.