A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males.
Giulia Brigante,Giorgia Spaggiari,Barbara Rossi,Antonio R. M. Granata,Manuela Simoni,Daniele Santi +5 more
TLDR
In this article, the effect of lockdown-related stress on the hypothalamic-pituitary-thyroid (HPT) axis in a cohort of young men was investigated.Abstract:
Trying to manage the dramatic coronavirus disease 2019 (COVID-19) infection spread, many countries imposed national lockdown, radically changing the routinely life of humans worldwide. We hypothesized that both the pandemic per se and the consequent socio-psychological sequelae could constitute stressors for Italian population, potentially affecting the endocrine system. This study was designed to describe the effect of lockdown-related stress on the hypothalamic-pituitary-thyroid (HPT) axis in a cohort of young men. A prospective, observational clinical trial was carried out, including patients attending the male infertility outpatient clinic before and after the national lockdown for COVID-19 pandemic. The study provided a baseline visit performed before and a follow-up visit after the lockdown in 2020. During the follow-up visit, hormonal measurements, lifestyle habits and work management were recorded. Thirty-one male subjects were enrolled (mean age: 31.6 ± 6.0 years). TSH significantly decreased after lockdown (p = 0.015), whereas no significant changes were observed in the testosterone, luteinising hormone, follicle-stimulating hormone, estradiol and prolactin serum levels. No patient showed TSH serum levels above or below reference ranges, neither before nor after lockdown. Interestingly, TSH variation after lockdown was dependent on the working habit change during lockdown (p = 0.042). We described for the first time a TSH reduction after a stressful event in a prospective way, evaluating the HPT axis in the same population, before and after the national lockdown. This result reinforces the possible interconnection between psychological consequences of a stressful event and the endocrine regulation.read more
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The crucial role of prolactin-lactogenic hormone in Covid-19
TL;DR: In this paper , the authors tried to find the potential anti-inflammatory or pro-inflammatory role of Prolactin (PRL) in Covid-19, which is a peptide hormone secreted from anterior pituitary involved in milk production in the females.
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Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic
Dong Weiwei,Wu Bei,Wang Hong,Wu Cailan,Shao HaiLin,Xu Donghong,Wang Xiaolai,Hao Zhaohu,Li Shijun,Tan Jian,Jiaping Qiang +10 more
TL;DR: People in the northern area of Tianjin during the COVID-19 outbreak were at an increased risk of higher FT4, lower FT3, and lower TSH, and the HAMA scores increased in emergency situations and were positively correlated with the levels of FT3 and FT4.
Journal ArticleDOI
Human fertility and sleep disturbances: A narrative review.
Giorgia Spaggiari,Marilina Romeo,Livio Casarini,Antonio R. M. Granata,Manuela Simoni,Daniele Santi +5 more
TL;DR: In this paper , the connection between sleep dysregulation and human fertility was classified according to specific sleep characteristics, such as sleep duration, quality, and habits, and possible physio-pathological mechanisms proposed to support the link between sleep and fertility were summarized.
Journal ArticleDOI
The effects of prolactin on the immune system, its relationship with the severity of COVID-19, and its potential immunomodulatory therapeutic effect
Yousef Rasmi,Ladan. Jalali,Saliha Khalid,Ameneh Shokati,Poonam Tyagi,Alpaslan Ozturk,Amir Nasimfar +6 more
TL;DR: Prolactin (PRL) is an endocrine hormone secreted by the anterior pituitary gland that has a variety of physiological effects, including milk production, immune system regulation, and anti-inflammatory effects as discussed by the authors .
References
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Carole A. Spencer,Jonathan S. LoPresti,A. Patel,Richard B. Guttler,A. Eigen,D. Shen,David S. Gray,John T. Nicoloff +7 more
TL;DR: The physiological relationship between serum TSH and free T4 levels had plateaued after decreasing in parallel to the slope of the steady state relationship, suggesting that the degree of T4 suppression of TSH can be predicted from an individual's pituitary TSH/free T4 set-point and the magnitude of the serum T4 elevation achieved.
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