Journal ArticleDOI
A rat model of smoke inhalation injury: influence of combustion smoke on gene expression in the brain.
Heung M. Lee,Heung M. Lee,George H. Greeley,David N. Herndon,David N. Herndon,Madhumita Sinha,Bruce A. Luxon,Ella W. Englander,Ella W. Englander +8 more
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TLDR
The new rat model affords insight into the complex molecular pathophysiology of smoke inhalation in the brain, and microarray analysis revealed increased brain expression of nitric oxide synthase (NOS) and NOS ligand after inhalation of smoke.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2005-11-01. It has received 34 citations till now. The article focuses on the topics: Smoke inhalation & Smoke Inhalation Injury.read more
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Journal ArticleDOI
Review of the health effects of wildland fire smoke on wildland firefighters and the public
Olorunfemi Adetona,Timothy E. Reinhardt,Joe Domitrovich,George Broyles,Anna M. Adetona,Michael T. Kleinman,Roger D. Ottmar,Luke P. Naeher +7 more
TL;DR: Longitudinal studies of wildland firefighters during and/or after the firefighting career could help elucidate some of the unknown health impacts of cumulative exposure to wildland fire smoke, establish occupational exposure limits and help determine the types of exposure controls that may be applicable to the occupation.
Journal ArticleDOI
Mitochondrial dysfunction, oxidative stress, and major depressive disorder.
TL;DR: Evaluation of mitochondrial dysfunction in specific tissues may broaden the perspective of depression beyond theories about neurotransmitters or receptor sites, and may explain the persistent signs and symptoms of depression.
Journal ArticleDOI
Carbon Monoxide–Sensitive Apoptotic Death of Erythrocytes
Elisabeth Lang,Syed M. Qadri,Kashif Jilani,Christine Zelenak,Adrian Lupescu,Erwin Schleicher,Florian Lang +6 more
TL;DR: Exposure of erythrocytes for 24 hr to CORM‐2 significantly increased COHb, [ Ca2+ ]i, forward scatter, annexin‐V‐binding and haemolysis, an effect largely due to Ca2- entry and partially reversed by O2 .
Journal ArticleDOI
Pathophysiology of tobacco smoke exposure: Recent insights from comparative and redox proteomics
Graziano Colombo,Marco Clerici,Daniela Giustarini,Nicola Portinaro,Giancarlo Aldini,Ranieri Rossi,Aldo Milzani,Isabella Dalle-Donne +7 more
TL;DR: The redox proteomic approach may also help identify biomarkers of exposure to tobacco smoke useful for preventing these effects or potentially predictive of the onset and/or progression of smoking-induced diseases as well as potential targets for therapeutic strategies.
Journal ArticleDOI
Long term environmental tobacco smoke activates nuclear transcription factor-kappa B, activator protein-1, and stress responsive kinases in mouse brain.
Sunil K. Manna,Thirumalai Rangasamy,Kimberly Wise,Shubhashish Sarkar,Shishir Shishodia,Shyam Biswal,Govindarajan T. Ramesh +6 more
TL;DR: Exposure to long-term cigarette smoke induces oxidative stress leading to activation of stress induced kinases and activation of proinflammatory transcription factors, which are related to oxidative stress related damage in different regions of the mouse brain.
References
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Journal ArticleDOI
Cluster analysis and display of genome-wide expression patterns
TL;DR: A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function.
Journal ArticleDOI
Hyperbaric Oxygen for Acute Carbon Monoxide Poisoning
Lindell K. Weaver,Ramona O. Hopkins,Karen J. Chan,Susan Churchill,C. Gregory Elliott,Terry P. Clemmer,James F. Orme,Frank Thomas,Alan H. Morris +8 more
TL;DR: Three hyperbaric-oxygen treatments within a 24-hour period appeared to reduce the risk of cognitive sequelae 6 weeks and 12 months after acute carbon monoxide poisoning.
Book ChapterDOI
Total Burn Care
Jong O. Lee,David N. Herndon +1 more
TL;DR: This work focuses on the part of nursing for Burned Patients and the systemic response to Burn Injury, which is concerned with psychosocial recovery, rescue, and recovery after injury.
Journal ArticleDOI
Iron and Iron-Handling Proteins in the Brain After Intracerebral Hemorrhage
TL;DR: The iron overload and upregulation of iron-handling proteins, including transferrin, transferrin receptor, and ferritin, in the brain after ICH suggest that iron could be a target for ICH therapy.
Journal ArticleDOI
Statistical implications of pooling RNA samples for microarray experiments
Xuejun Peng,Constance L. Wood,Eric M. Blalock,Kuey-Chu Chen,Philip W. Landfield,Arnold J. Stromberg +5 more
TL;DR: This study reveals that pooling biological samples appropriately is statistically valid and efficient for microarray experiments and optimal pooling design(s) can be found to meet statistical requirements while minimizing total cost.