A receptor for polymerized human and chimpanzee albumins on hepatitis B virus particles co-occurring with HBeAg.
TLDR
Results seem to suggest a possible role of the receptor on Dane particles (presently accepted hepatitis B virions) for polymerized albumin molecules in infecting hepatocytes both in humans and chimpanzees.About:
This article is published in Gastroenterology.The article was published on 1979-02-01 and is currently open access. It has received 179 citations till now. The article focuses on the topics: HBeAg & Hepatitis B virus.read more
Citations
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Reviews: Role of Albumin in Human Physiology and Pathophysiology
TL;DR: A review of the evolution and structure of albumin as well as a description of its colloidal and buffering properties is presented, including the importance of nutritional status on substrate availability, energy supply, and hormonal modulation.
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Reviews: The Role of Albumin in Human Physiology and Pathophysiology, Part III: Albumin and Disease States
TL;DR: The serum albumin level is one of several clinical parameters of the status of general health that results from alterations in the catabolic or anabolic rates, losses of albumin, or redistribution between the various fluid compartments of the body.
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Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection. Hepatocyte with cytoplasmic/membranous hepatitis B core antigen as a possible target for immune hepatocytolysis.
Chia-Ming Chu,Yun-Fan Liaw +1 more
TL;DR: It is suggested that hepatocytes with cytoplasmic/membranous HBcAg expression might be the target cells for immune hepatocytolysis in patients with chronic type B hepatitis.
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A hepatitis B surface antigen polypeptide (P31) with the receptor for polymerized human as well as chimpanzee albumins.
A Machida,Shinya Kishimoto,H Ohnuma,H Miyamoto,K. Baba,K. Oda,Tetsuo Nakamura,Yuzo Miyakawa,Makoto Mayumi +8 more
TL;DR: Polypeptides with the receptor for polymerized albumin may make an efficacious hepatitis B vaccine, because they could raise antibodies against the putative site on hepatitis B virus capable of binding with hepatocytes to initiate the infection.
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Nucleotide sequence of a cloned hepatitis B virus genome, subtype ayr: comparison with genomes of the other three subtypes.
Hiroaki Okamoto,Mitsunobu Imai,Mayumi Shimozaki,Yuji Hoshi,Hisao Iizuka,Tohru Gotanda,Fumio Tsuda,Yuzo Miyakawa,Makoto Mayumi +8 more
TL;DR: A hydrophilic sequence of 19 amino acid residues, coded for by the pre-S(2) region and implicated in the presumed hepatotropism of HBV, was possessed in common by HBV/adr,HBV/ayr and HBV-adw, and differed in HBV /adw by only one residue at the 9th position.
References
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Virus-like particles in serum of patients with australia-antigen-associated hepatitis
TL;DR: Virus-like particles about 42 nm in diameter have been found in multiple serum specimens from three Australia-antigen-positive hepatitis patients, and it is suggested that these particles may be complete virus and that the much more numerous 22 nm.
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Chemical Coupling of Proteins to Agarose
TL;DR: This method of activation and coupling is gentle and therefore particularly useful for the production of immunosorbents and insoluble enzymes.
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DNA polymerase associated with human hepatitis B antigen.
P M Kaplan,P M Kaplan,P M Kaplan,Richard L. Greenman,Richard L. Greenman,Richard L. Greenman,John L. Gerin,John L. Gerin,John L. Gerin,Robert H. Purcell,Robert H. Purcell,Robert H. Purcell,William S. Robinson,William S. Robinson,William S. Robinson +14 more
TL;DR: DNA polymerase activity was detected in each of eight preparations of concentrated human hepatitis B antigen (HBAg) rich in Dane particles prepared by high-speed centrifugation of antigen-positive human plasma and in none of seven control preparations prepared in the same way from HBAg-negative plasma.
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E Antigen and Anti-E in the Serum of Asymptomatic Carrier Mothers as Indicators of Positive and Negative Transmission of Hepatitis B Virus to Their Infants
TL;DR: E antigen may be used as an indicator of transmission, and antibody to e as that of absence of transmission of hepatitis B virus from carrier mothers to children, according to results of testing of serum samples of 23 pregnant women.
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Hemagglutination Assay for Antigen and Antibody Associated with Viral Hepatitis
Girish N. Vyas,N. R. Shulman +1 more
TL;DR: The hemagglutination test has the sensitivity and rapidity of the best tests available, is simpler to perform, and lends itself to large-scale screening of blood donors.