Journal ArticleDOI
A study of degeneration and regeneration in the divided rat sciatic nerve based on electron microscopy. I. The traumatic degeneration of myelin in the proximal stump of the divided nerve.
TLDR
In this paper, the authors examined the processes of traumatic degeneration of myelin in the proximal stump of divided rat sciatic nerves with the electron microscope, revealing a complete and coherent series of Schwann cells which are progressively more advanced in the degradation of the myelin.Abstract:
Examination of the processes of traumatic degeneration of myelin in the proximal stump of divided rat sciatic nerves with the electron microscope reveals a complete and coherent series of Schwann cells which are progressively more advanced in the degradation of the myelin. The earlier stages appear to be a wrinkling and distortion of the myelin lamellae, followed by erosion of the circumferential lamellae with subsequent loss of cohesion and fragmentation of the myelin systems. Retraction of the myelin from the region of the node of Ranvier is observed. Myelin debris in the cytoplasm of Schwann cells occurs as vacuoles containing membranous material and pale staining globular inclusions which may develop from the membrane containing vacuoles. Cells containing similar inclusions are present ‘free’ in the endoneurium. The presence of similar cells associated with axons and only partly covered by basement membrane suggests that the cells ‘free’ in the endoneurium are ‘transformed’ Schwann cells digesting their myelin. These cells are most frequent between 3 and 6 days after nerve section and gradually disappear thereafter. We did not see any indications that cells other than Schwann cells were extensively involved in the traumatic degeneration of myelin.read more
Citations
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Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma
TL;DR: No signs of excitatory on inhibitory interaction were detected between volleys in one group of nerve fibers and the activity in other groups of fibers in the neuroma, suggesting that alpha blocking agents might be useful to test if the sympathetic system is involved in particular pains.
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Spatial‐Temporal progress of peripheral nerve regeneration within a silicone chamber: Parameters for a bioassay
TL;DR: The spatial‐temporal progress of peripheral nerve regeneration across a 10‐mmgap within a silicone chamber was examined and the parameters of a morphologic assay for regeneration in this chamber model can be used to investigate cellular and molecular mechanisms underlying the success of peripheral nerves regeneration.
Journal ArticleDOI
Peripheral nerve regeneration through guidance tubes.
TL;DR: This review focuses on artificial conduits, nerve regeneration through them, and an account of various synthetic materials that comprise these tubes in experimental animal and clinical trials.
Journal ArticleDOI
Assembly of a new growth cone after axotomy: the precursor to axon regeneration
TL;DR: In axons that lack regenerative capacity, such as those of the mammalian CNS, several of the steps required for regeneration fail, and these axons do not begin the growth process.
Journal ArticleDOI
A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo.
Ilaria Napoli,Luke A. Noon,Sara Ribeiro,Ajay P. Kerai,Simona Parrinello,Laura H. Rosenberg,Melissa J. Collins,Marie C. Harrisingh,Ian J. White,Ashwin Woodhoo,Alison C. Lloyd +10 more
TL;DR: It is demonstrated that activation of an inducible Raf-kinase transgene in myelinated Schwann cells is sufficient to control this plasticity by inducing severe demyelination in the absence of axonal damage, with the period of demYelination/ataxia determined by the duration of Raf activation.
References
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Journal ArticleDOI
Yolk protein uptake in the oocyte of the mosquito aedes aegypti. l.
Thomas F. Roth,Keith R. Porter +1 more
TL;DR: Preliminary radioautographs, and certain morphological features of the fat body, ovary, and midgut, suggest that the midGut is the principal site of yolk protein synthesis in the mosquito.
Journal ArticleDOI
Lysosome function in the regulation of the secretory process in cells of the anterior pituitary gland.
TL;DR: In secretory cells, lysosomes function in the regulation of the secretory process by providing a mechanism which takes care of overproduction of secretory products.
Journal ArticleDOI
Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells
TL;DR: Cells from a variety of sources, principally differentiating fibroblasts and smooth muscle cells from neonatal chicken and mammalian tissues and from organ cultures of chicken duodenum, were used as materials for an electron microscopic study on the formation of rudimentary cilia.
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THE "VESICLE IN A BASKET" : A Morphological Study of the Coated Vesicle Isolated from the Nerve Endings of the Guinea Pig Brain, with Special Reference to the Mechanism of Membrane Movements
Toku Kanaseki,Ken Kadota +1 more
TL;DR: In this article, it was shown that the hairlike projections are actually the superimposed visual images of the regular hexagons and pentagons of the network composing the basketwork.