Journal ArticleDOI
Peripheral nerve regeneration through guidance tubes.
TLDR
This review focuses on artificial conduits, nerve regeneration through them, and an account of various synthetic materials that comprise these tubes in experimental animal and clinical trials.Abstract:
Biological nerve grafts have been extensively utilized in the past to repair peripheral nerve injuries. More recently, the use of synthetic guidance tubes in repairing these injuries has gained in popularity. This review focuses on artificial conduits, nerve regeneration through them, and an account of various synthetic materials that comprise these tubes in experimental animal and clinical trials. It also lists and describes several biomaterial considerations one should regard when designing, developing, and manufacturing potential guidance channel candidates. In the future, it it likely that the most successful synthetic nerve conduit will be one that has been fabricated with some of these strategies in mind.read more
Citations
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Journal ArticleDOI
Degeneration and regeneration of the nervous system
Journal ArticleDOI
FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy
S. Kehoe,X.F. Zhang,Daniel Boyd +2 more
TL;DR: A comprehensive reference for clinicians which may facilitate optimal material/device selection for peripheral nerve repair and for materials scientists, this review highlights predicate devices and evaluation methodologies, offering an insight into current deficiencies associated with state-of-the-art materials.
Journal ArticleDOI
A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery
TL;DR: This review critically discusses the advances in biomaterial-based NGCs, their limitations and where future improvements may be required.
Journal ArticleDOI
Processed allografts and type I collagen conduits for repair of peripheral nerve gaps.
Elizabeth L. Whitlock,Sami H. Tuffaha,Janina P. Luciano,Ying Yan,Daniel A. Hunter,Christina K. Magill,Amy M. Moore,Alice Y. Tong,Susan E. Mackinnon,Gregory H. Borschel +9 more
TL;DR: It is concluded that, particularly in a long gap model, nerve graft alternatives fail to confer the regenerative advantages of an isograft, but AxoGen processed allografts are superior to a currently available conduit‐style nerve guide, the Integra NeuraGen®.
Journal ArticleDOI
Bioactive Nanofibers: Synergistic Effects of Nanotopography and Chemical Signaling on Cell Guidance
Shyam Patel,Kyle Kurpinski,Ryan J. Quigley,Hongfeng Gao,Benjamin S. Hsiao,Mu-ming Poo,Song Li +6 more
TL;DR: Aligned and bioactive nan ofibrous scaffolds are developed by immobilizing extracellular matrix protein and growth factor onto nanofibers, which simulated the physical and biochemical properties of native matrix fibrils, which induced neurite outgrowth and enhanced skin cell migration during wound healing.
References
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Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
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Journal ArticleDOI
Degeneration and regeneration of the nervous system
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FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy
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