A superabsorbent polymer-containing wound dressing efficiently sequesters MMPs and inhibits collagenase activity in vitro
Reads0
Chats0
TLDR
In vitro data confirm the positive effect of the SAP wound dressing observed in vivo and suggest that it should be specifically useful for highly exuding wounds with an elevated proteolytic activity that needs to be reduced to support healing.Abstract:
Superabsorbent polymer (SAP)-containing wound dressings present a valuable and unique category of wound management products. An in vitro approach was used to assess the effects of a new SAP dressing in treatment of non-healing wounds. It was shown that the SAP dressing possesses a significant binding capacity for MMP-2 and MMP-9 in vitro (P < 0.001). The inclusion of the bound proteases was so strong that no MMP-2 and only marginal amounts of MMP-9 were released from the dressing samples in a subsequent elution step. In addition, the SAP dressing was able to take up collagenase and reduce its activity in vitro. However, collagenase was not completely inactivated upon binding and enzyme-mediated substrate turnover could be observed at the dressings. In conclusion, in vitro data confirm the positive effect of the SAP wound dressing observed in vivo. The findings suggest that it should be specifically useful for highly exuding wounds with an elevated proteolytic activity that needs to be reduced to support healing.read more
Citations
More filters
Journal ArticleDOI
Clinical efficacy of dressings for treatment of heavily exuding chronic wounds
TL;DR: Application of dressings that remove and sequester excess amounts of wound fluid may not only help in restoring the correct balance of moisture, but also support the wound healing process by preventing tissue deterioration caused by abundant protease activity.
Journal ArticleDOI
Matrix metalloproteinases in the wound microenvironment: therapeutic perspectives
TL;DR: Main representatives of MMPs family are described, their role in pathophysiology of chronic wounds, as well as current and possible therapeutic strategies for modulation of M MPs' activity, which may be useful in management of Chronic wounds.
Journal ArticleDOI
Evaluation of the Efficacy of Highly Hydrophilic Polyurethane Foam Dressing in Treating a Diabetic Foot Ulcer
TL;DR: Results indicate that the highly hydrophilic polyurethane foam dressing may provide an effective treatment strategy for diabetic foot ulcers.
Journal ArticleDOI
In Vitro Evaluation of Betafoam, a New Polyurethane Foam Dressing.
TL;DR: Betafoam had the smallest pore size, the fastest fluid absorption time, greatest fluid absorption, and best retention capacities among the tested foam dressings, and demonstrated the lowest cytotoxicity to the fibroblasts.
Journal ArticleDOI
Topical photochemical nitric oxide release from porous poly(vinyl alcohol) membrane for visible light modulation of dermal vasodilation
TL;DR: In this article, phase inversion technique was used to prepare porous membranes of polyvinyl alcohol (PVA) functionalized with NO-releasing S-nitrosothiol (SNO) moieties.
References
More filters
Book
Introduction to Polymers
Robert J. Young,Chan I. Chung +1 more
TL;DR: In this article, the authors discuss the history of polymers and their application in the field of chemical engineering, including the origins of polymer science and the Polymer Industry, as well as a discussion of the role of elastic deformation in polymers.
Journal ArticleDOI
Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors.
Naomi Trengove,Michael Stacey,Shawn P. Macauley,Neil T. Bennett,Jane S. Gibson,Frank Burslem,Gillian Murphy,Gregory S. Schultz +7 more
TL;DR: The elevated levels of matrix metalloproteinase activity decreased significantly as healing occurs in chronic leg ulcers, which parallels the processes observed in normally healing acute wounds and supports the case for the addition of protease inhibitors in chronic wounds in conjunction with any treatments using growth factors.
Journal ArticleDOI
Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9
TL;DR: The results suggest that non-healing ulcers develop an environment containing high levels of activated metalloproteinases, which may result in chronic tissue turnover and failed wound closure.
Journal ArticleDOI
The proteolytic environment of chronic wounds
TL;DR: The current understanding of the proteolytic enzymes found in chronic wounds is discussed and attempts to relate this information to the abundant presence of neutrophils.
Journal ArticleDOI
Ability of chronic wound fluids to degrade peptide growth factors is associated with increased levels of elastase activity and diminished levels of proteinase inhibitors.
Dorne R. Yager,Stephen M. Chen,Susan I. Ward,Oluyinka O. Olutoye,Robert F. Diegelmann,I. Kelman Cohen +5 more
TL;DR: The ability of some chronic nonhealing wounds to rapidly degrade exogenously added growth factors has important implications with regard to past and future clinical attempts to use peptide growth factors to treat these types of problem wounds.