Journal ArticleDOI
Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9
TLDR
The results suggest that non-healing ulcers develop an environment containing high levels of activated metalloproteinases, which may result in chronic tissue turnover and failed wound closure.About:
This article is published in Journal of Investigative Dermatology.The article was published on 1993-07-01. It has received 721 citations till now. The article focuses on the topics: Chronic wound.read more
Citations
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Journal ArticleDOI
Interactions between extracellular matrix and growth factors in wound healing.
TL;DR: These interactions between growth factors and ECM are bidirectional, and how they are altered in difficult to heal or chronic wounds is discussed, and treatment implications are briefly considered.
Journal ArticleDOI
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
Anca Sindrilaru,Thorsten Peters,Stefan Wieschalka,Corina Baican,Adrian Baican,Henriette Peter,Adelheid Hainzl,Susanne Schatz,Yu Qi,Andrea Schlecht,Johannes M. Weiss,Meinhard Wlaschek,Cord Sunderkötter,Karin Scharffetter-Kochanek +13 more
TL;DR: It is shown that iron overloading of macrophages--as was found to occur in human chronic venous leg ulcers and the mouse model--induced a macrophage population in situ with an unrestrained proinflammatory M1 activation state, which perpetuated inflammation and induced a p16(INK4a)-dependent senescence program in resident fibroblasts, eventually leading to impaired wound healing.
Patent
Wound treatment employing reduced pressure
TL;DR: In this article, a wound treatment apparatus is provided in which a fluid impermeable wound cover is sealed over a wound site, and a screen in the form of an open-cell foam screen or a rigid porous screen is placed beneath the wound cover over the wound.
Journal ArticleDOI
Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors.
Naomi Trengove,Michael Stacey,Shawn P. Macauley,Neil T. Bennett,Jane S. Gibson,Frank Burslem,Gillian Murphy,Gregory S. Schultz +7 more
TL;DR: The elevated levels of matrix metalloproteinase activity decreased significantly as healing occurs in chronic leg ulcers, which parallels the processes observed in normally healing acute wounds and supports the case for the addition of protease inhibitors in chronic wounds in conjunction with any treatments using growth factors.
Journal ArticleDOI
Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)
Philippe E. Van den Steen,Bénédicte Dubois,Inge Nelissen,Pauline M. Rudd,Raymond A. Dwek,Ghislain Opdenakker +5 more
TL;DR: The ability of gelatinase B to degrade components of the extracellular matrix and to regulate the activity of a number of soluble proteins confers an important role in various physiological and pathological processes, including reproduction, growth, development, inflammation, and vascular and proliferative diseases.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Matrix metalloproteinases and their inhibitors in connective tissue remodeling.
TL;DR: Latency is overcome by physical, chemical, and enzymatic treatments that separate the cysteine residue from the zinc Expression of the metalloproteinases is switched on by a variety of agents acting through regulatory elements of the gene, particularly the AP‐1 binding site.
Journal ArticleDOI
Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates.
Christa Heussen,Eugene B. Dowdle +1 more
TL;DR: A new technique is described for the electrophoretic analysis of plasminogen activators in sodium dodecyl sulfate-polyacrylamide gels containing copolymerized pl asminogen and gelatin, which can be used to detect as little as 1 mU of urokinase and effectively distinguishes between melanoma- and u rokinase-type plasmineg activators.