Acoustic Radiation Force-Driven Assessment of Myocardial Elasticity Using the Displacement Ratio Rate (DRR) Method
Richard R. Bouchard,Stephen J. Hsu,Mark L. Palmeri,Ned C. Rouze,Kathryn R. Nightingale,Gregg E. Trahey +5 more
TLDR
A novel ARF-based imaging technique, the displacement ratio rate (DRR) method, was developed to rank the relative stiffnesses of dynamically varying tissue, and results predicted a similar cyclic stiffness variation to that offered by velocimetry while being insensitive to variations in applied radiation force.Abstract:
A noninvasive method of characterizing myocardial stiffness could have significant implications in diagnosing cardiac disease. Acoustic radiation force (ARF)–driven techniques have demonstrated their ability to discern elastic properties of soft tissue. For the purpose of myocardial elasticity imaging, a novel ARF-based imaging technique, the displacement ratio rate (DRR) method, was developed to rank the relative stiffnesses of dynamically varying tissue. The basis and performance of this technique was demonstrated through numerical and phantom imaging results. This new method requires a relatively small temporal (<1 ms) and spatial (tenths of mm2) sampling window and appears to be independent of applied ARF magnitude. The DRR method was implemented in two in vivo canine studies, during which data were acquired through the full cardiac cycle by imaging directly on the exposed epicardium. These data were then compared with results obtained by acoustic radiation force impulse (ARFI) imaging and shear wave velocimetry, with the latter being used as the gold standard. Through the cardiac cycle, velocimetry results portray a range of shear wave velocities from 0.76–1.97 m/s, with the highest velocities observed during systole and the lowest observed during diastole. If a basic shear wave elasticity model is assumed, such a velocity result would suggest a period of increased stiffness during systole (when compared with diastole). Despite drawbacks of the DRR method (i.e., sensitivity to noise and limited stiffness range), its results predicted a similar cyclic stiffness variation to that offered by velocimetry while being insensitive to variations in applied radiation force.read more
Citations
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High-contrast ultrafast imaging of the heart
TL;DR: Spatial coherent compounding provided a strong improvement of the imaging quality, even with a small number of transmitted diverging waves and a high frame rate, which allows imaging of the propagation of electromechanical and shear waves with good image quality.
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Measurement of Viscoelastic Properties of In Vivo Swine Myocardium Using Lamb Wave Dispersion Ultrasound Vibrometry (LDUV)
TL;DR: It is demonstrated that wave velocity measurements and Lamb wave theory allow one to estimate the variation of viscoelastic moduli of the myocardial walls in vivo throughout the course of the cardiac cycle.
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Ultrafast Harmonic Coherent Compound (UHCC) Imaging for High Frame Rate Echocardiography and Shear-Wave Elastography
TL;DR: The quality of transthoracic images of the heart was found to be improved with the number of pulse-inverted diverging waves with a reduction of the imaging mean clutter level up to 13.8 dB when compared against UCC at the fundamental frequency, which demonstrated that UHCC B-mode imaging is promising for imaging deep tissues exposed to aberration sources with a high FR.
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Intracardiac Echocardiography Measurement of Dynamic Myocardial Stiffness with Shear Wave Velocimetry
TL;DR: The techniques used to overcome the challenges of using a small probe to perform ARF-driven shear-wave velocimetry are described and in vivo porcine data is presented showing the effectiveness of this method in the interventricular septum.
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Noninvasive Assessment of Wall-Shear Rate and Vascular Elasticity using Combined ARFI/SWEI/Spectral Doppler Imaging System
TL;DR: Two novel ARFI based imaging techniques were developed to form co-registered depictions of B-mode echogenicity, ARFI displacements, ARF-excited transverse wave velocity estimates and estimates of wall-shear rate throughout the cardiac cycle.
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