Journal ArticleDOI
Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine.
R.J. Haslam,J.A. Lynham +1 more
TLDR
The results suggest that the activation and inhibition of platelet adenylatecyclase by adenosine or 2-chloroadenosine are independent processes mediated by different components of a receptor-adenylate cyclase complex.About:
This article is published in Life Sciences.The article was published on 1972-12-08. It has received 122 citations till now. The article focuses on the topics: Cyclase activity & Cyclase.read more
Citations
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Journal ArticleDOI
Two distinct adenosine-sensitive sites on adenylate cyclase
Constantine Londos,J. Wolff +1 more
TL;DR: Comparison of data indicates that adenosine-reactive "P" and "R" sites are present generally and are explained by the presence of both sites on a single adenylate cyclase.
Journal ArticleDOI
Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP.
TL;DR: The results show that cyclic AMP plays no significant role in the responses of platelets to aggregating agents in the absence of compounds that increase the platelet cyclicAMP concentration above the resting value.
Journal ArticleDOI
Regulation of adenylate cyclase by adenosine.
John N. Fain,Craig C. Malbon +1 more
TL;DR: A unitary model is proposed which explains both the stimulatory and inhibitory effects of low concentrations of adenosine on adenylate cyclase as well as the effects of methyl xanthines on cyclic AMPs in many tissues.
Journal ArticleDOI
The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation.
TL;DR: It is concluded that adrenaline, thrombin, 5HT, and vasopressin each can induce primary aggregation of human platelets by a mechanism independent of extracellular ADP.
Journal ArticleDOI
Mechanism of action of dipyridamole
TL;DR: The antithrombotic effects of dipyridamole in a baboon model of arterial thromboembolism are unaffected by simultaneous administration of dazoxiben, a specific thromboxane synthetase inhibitor, but are optimally potentiated by the simultaneous addition of aspirin in doses of 20 mg/kg/day.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal Article
A simple, sensitive method for the assay of adenyl cyclase.
TL;DR: The purity of the nucleotide has been assessed enzymatically, by utilizing a purified cyclic nucleotide phosphodiesterase, and the method made possible the measurement of enzyme activities in tissue weighing less than 1 mg.
Journal Article
The Effect of Adenosine and Adenine Nucleotides on the Cyclic Adenosine 3',5'-Phosphate Content of Guinea Pig Cerebral Cortex Slices
Albert Sattin,T. W. Rall +1 more
TL;DR: Changes in the tissue compartmentation of adenine nucleotides probably play a major role in producing the previously observed increase of cyclic adenosine 39,59-phosphate during electrical stimulation of slices.
Journal ArticleDOI
The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3':5'-cyclic monophosphate in platelets.
D. C. B. Mills,J. B. Smith +1 more
TL;DR: Significant positive correlations were found between the radioactivity of 3':5'-cyclic AMP in platelets measured at the time of addition of the aggregating agent (ADP) and the extent to which the aggregation was inhibited.
Related Papers (5)
The Effect of Adenosine and Adenine Nucleotides on the Cyclic Adenosine 3',5'-Phosphate Content of Guinea Pig Cerebral Cortex Slices
Albert Sattin,T. W. Rall +1 more
The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3':5'-cyclic monophosphate in platelets.
D. C. B. Mills,J. B. Smith +1 more