Effects of Adenosine Nucleosides on Adenylate Cyclase, Phosphodiesterase, Cyclic Adenosine Monophosphate Accumulation, and Lipolysis in Fat Cells
TLDR
Data indicate that marked inhibition by nucleosides of the increase in total cyclic AMP accumulation seen 5 min after the addition of theophylline, norepinephrine, or nore Pinephrine plus theophyLLine is not necessarily associated with any decrease in lipolysis.About:
This article is published in Journal of Biological Chemistry.The article was published on 1972-11-10 and is currently open access. It has received 308 citations till now. The article focuses on the topics: Cyclic adenosine monophosphate & Adenosine A1 receptor.read more
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Adenosine regulates via two different types of receptors, the accumulation of cyclic amp in cultured brain cells
TL;DR: In cell cultures of glial character derived from perinatal mouse brain adenosine elicits two effects; at submicromolar concentrations it inhibits the increase in the intracellular level of cyclic AMP caused by β‐adrenoceptor agonists and at concentrations above micromolar it increases the level of CyclicAMP in the cultures.
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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
Russell A. Miller,Qingwei Chu,Jianxin Xie,Marc Foretz,Marc Foretz,Marc Foretz,Benoit Viollet,Benoit Viollet,Benoit Viollet,Morris J. Birnbaum +9 more
TL;DR: A novel mechanism by which metformin antagonizes the action of glucagon, thus reducing fasting glucose levels and suggesting an approach for the development of antidiabetic drugs is provided.
Journal ArticleDOI
Two distinct adenosine-sensitive sites on adenylate cyclase
Constantine Londos,J. Wolff +1 more
TL;DR: Comparison of data indicates that adenosine-reactive "P" and "R" sites are present generally and are explained by the presence of both sites on a single adenylate cyclase.
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Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines
John W. Daly,John W. Daly,Robert F. Bruns,Robert F. Bruns,Solomon H. Snyder,Solomon H. Snyder +5 more
TL;DR: Behavior, electrophysiological, and biochemical effects of alkylxanthines are consistent with the hypothesis that the central stimulatory actions of caffeine and theophylline are due in large part to antagonism of central adenosine receptors.
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Adenosine and the concept of ‘retaliatory metabolites’
TL;DR: Adenosine can modulate a bewildering array of physiological processes including vascular tone, hormone action, neural function, platelet aggregation and lymphocyte differentiation, and its unique mechanism of formation suggests instead that adenosine is a new type of cellular regulator.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Metabolism of isolated fat cells. i. effects of hormones on glucose metabolism and lipolysis.
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A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate
TL;DR: A simple and sensitive assay for adenosine 3':5'-cyclic monophosphate (cAMP) has been developed that is based on competition for protein binding of the nucleotide, presumably to a cAMP-dependent protein kinase.
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A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.
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Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells.
TL;DR: In combination, epinephrine and caffeine acted synergistically, producing large increases in cyclic AMP, indicating that, as in other systems, the catecholamines act to stimulate adenyl cyclase and the methyl xanthines act to inhibit the cyclic nucleotide phosphodiesterase.
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Metabolism of isolated fat cells. i. effects of hormones on glucose metabolism and lipolysis.
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