Activation of heparin cofactor II by dermatan sulfate.
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TLDR
It is suggested that HCII is the only thrombin inhibitor in human plasma that can be activated by dermatan sulfate.About:
This article is published in Journal of Biological Chemistry.The article was published on 1983-06-10 and is currently open access. It has received 428 citations till now. The article focuses on the topics: Heparin cofactor II & Dermatan sulfate.read more
Citations
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Antithrombotic activity of avian crown dermatan sulfate
Mamoru Kyogashima,Junichi Onaya,Satoshi Miyauchi,Mikio Arai,Yuniko Shibata,Akihisa Suda,Tokiko Sakai,Yumiko Takada,Akikazu Takada +8 more
TL;DR: In vivo, avian crown dermatan sulfate more effectively prevented the development of thrombus in a rat deep vein thrombosis model and in an in vitro test, bovine intestine dermatans sulfate exhibited stronger effects on stimulation of heparin cofactor II and activation of Glu-plasminogen by tissue plasminogens activator.
Journal ArticleDOI
Evolution of thrombosis.
TL;DR: Thrombi undergo constant structural change as they age and are gradually replaced by fibrin in the arterial and venous circulation.
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Tolerability and Clinical Efficacy of Desmin in the Treatment of Superficial Thrombovaricophlebitis
Andreozzi Gm,Signorelli S,L. Di Pino,Romeo Martini,E. Marchitelli,A. Pinto,S. Romeo,Villiam Zamboni,Ernesto Palazzini +8 more
TL;DR: Desmin proved capable of effectively improving the symptoms of patients affected by thrombovari cophlebitis, inducing rapid regression by the tenth day of treatment, and the systemic tolerability and local tolerance of the drug was good.
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Anticoagulant activity of a dermatan sulfate from the skin of the shark Scyliorhinus canicula.
Manel Dhahri,Mohamed Ben Mansour,Isabelle Bertholon,Véronique Ollivier,Naceur A. Boughattas,Mohsen Hassine,Martine Jandrot-Perrus,Frédéric Chaubet,Raoui M. Maaroufi +8 more
TL;DR: The sharkskin dermatan sulfate constitutes a potentially useful drug of interest in anticoagulant therapy and had no effect on platelet aggregation and activation induced by various agonists.
References
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Journal ArticleDOI
A modified uronic acid carbazole reaction
T. Bitter,Helen Muir +1 more
TL;DR: It has been found possible to distinguish betweenHeparin, heparin derivatives, and other polyuronides of connective tissue by comparing the effect of chlorides on the color yield in both procedures by modifying Dische's carbazole reaction for uronic acid in the presence of borate.
Journal ArticleDOI
The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor
TL;DR: It is suggested that heparin binds to the inhibitor and causes a conformational change which results in a more favorable exposure of the arginine reactive site, allowing a rapid interaction with thrombin.
Journal ArticleDOI
Glycosaminoglycans and their binding to biological macromolecules.
Ulf Lindahl,Magnus Höök +1 more
TL;DR: STRUCTURE and BIOSYNTHESIS of GL YCOSAMINOGL YCANS: Foundations and biosynthesis of GL ycans.
Journal ArticleDOI
Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma.
TL;DR: A previously unrecognized heparin-dependent inhibitor of thrombin from human plasma is isolated and is a relatively ineffective inhibitor of coagulation factor Xa.
Journal ArticleDOI
The kinetics of hemostatic enzyme-antithrombin interactions in the presence of low molecular weight heparin.
TL;DR: It is demonstrated that binding of heparin to antithrombin is required for the mucopolysaccharide-dependent enhancement in the rates of neutralization of thrombin, factor IXa, factor Xa, or plasmin by the protease inhibitor.
Related Papers (5)
Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma.
Structure of a dermatan sulfate hexasaccharide that binds to heparin cofactor II with high affinity.
The protease specificity of heparin cofactor II. Inhibition of thrombin generated during coagulation.
K A Parker,Douglas M. Tollefsen +1 more