Activity in the Medial Temporal Lobe Predicts Memory Strength, Whereas Activity in the Prefrontal Cortex Predicts Recollection
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TLDR
In a source memory study, a novel approach to data analysis was used that allowed item memory strength and source memory strength to be assessed independently and suggested that activity in the medial temporal lobe is predictive of subsequent memory strength, whereas activity in prefrontal cortex is predicted of subsequent recollection.Abstract:
Functional magnetic resonance imaging studies of recognition memory have often been interpreted to mean that the hippocampus supports recollection and that the adjacent perirhinal cortex supports familiarity. Other work points out that these studies have confounded recollection and familiarity with strong and weak memories. In a source memory study, we used two novel approaches to data analysis that allowed item memory strength and source memory strength to be assessed independently. First, we identified regions in both hippocampus and perirhinal cortex in which activity varied as a function of subsequent item memory strength while source memory strength was held constant at chance levels. Second, we identified regions in prefrontal cortex in which activity varied as a function of subsequent source memory strength while item memory strength was held constant. These findings suggest that activity in the medial temporal lobe is predictive of subsequent memory strength, whereas activity in prefrontal cortex is predictive of subsequent recollection.read more
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The Nature of Recollection and Familiarity: A Review of 30 Years of Research
TL;DR: For instance, the authors found that recall is more sensitive than familiarity to response speeding, division of attention, generation, semantic encoding, the effects of aging, and the amnestic effects of benzodiazepines, while familiarity is less sensitive to shifts in response criterion, fluency manipulations, forgetting over short retention intervals, and some perceptual manipulations.
Journal ArticleDOI
Improved assessment of significant activation in functional magnetic resonance imaging (fMRI) : use of a cluster-size threshold
Steven D. Forman,Jonathan D. Cohen,Mark Fitzgerald,William F. Eddy,Mark A. Mintun,Douglas C. Noll +5 more
TL;DR: In this article, an alternative approach, which relies on the assumption that areas of true neural activity will tend to stimulate signal changes over contiguous pixels, is presented, which can improve statistical power by as much as fivefold over techniques that rely solely on adjusting per pixel false positive probabilities.