Journal ArticleDOI
Activity of phasic neurosecretory cells during haemorrhage.
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TLDR
The results show the importance of pattern modulation in phasic neurones and suggest that the mechanism for vasopressin release differs from that described for oxytocin release during suckling.Abstract:
APPROXIMATELY 25% of the neurones projecting to the neurohypophysis from the paraventricular (PV) and supraoptic (SO) nuclei of the hypothalamus fire phasically and such a pattern is seldom seen in other hypothalamic cells1. Phasic neurones respond to osmotic stimuli2 but are rarely activated by suckling1,3. It is tempting therefore, to associate these cells with the secretion of vasopressin rather than oxytocin. The functional relationship of their phasic pattern to hormone release, however, remains obscure. We have studied phasic PV neurones during haemorrhage, which releases vasopressin, sometimes with small amounts of oxytocin4. Haemorrhage evoked changes in phasic units over a period long enough for a detailed analysis of their behaviour. Our results show the importance of pattern modulation in phasic neurones and suggest that the mechanism for vasopressin release differs from that described for oxytocin release during suckling1,3.read more
Citations
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Journal ArticleDOI
Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat
TL;DR: Observations indicate for the first time the existence of relatively direct conduction lines by which interoceptive information might be conveyed to limbic forebrain structures.
Journal ArticleDOI
The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat
TL;DR: The autoradiographic material, and additional double-labeling experiments, were used to identify and to characterize projections that interconnect the A1, A2 and A6 regions, as well as possible projections from these cell groups to the spinal cord.
Journal ArticleDOI
Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin
TL;DR: The hypothesis that nerve cells are true secreting cells, and act upon one other and upon the cells of other organs by the passage of a chemical substance of the nature of a ferment or proferment from the first cell to the second is formed.
Journal ArticleDOI
Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat
William J. Schwartz,Carolyn Beebe Smith,Leslie Davidsen,Helen E. Savaki,Louis Sokoloff,Marina Mata,David J. Fink,Harold Gainer +7 more
TL;DR: A difference in the metabolic response to functional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions.
Journal ArticleDOI
An immunohistochemical study of the organization of catecholaminergic cells and terminal fields in the paraventricular and supraoptic nuclei of the hypothalamus.
Larry W. Swanson,Larry W. Swanson,Larry W. Swanson,P.E. Sawchenko,P.E. Sawchenko,P.E. Sawchenko,A. Bérod,A. Bérod,A. Bérod,Boyd K. Hartman,Boyd K. Hartman,Boyd K. Hartman,K. B. Helle,K. B. Helle,K. B. Helle,D. E. Vanorden,D. E. Vanorden,D. E. Vanorden +17 more
TL;DR: It is concluded that adrenergic inputs to the paraventricular nucleus may influence cells that project to the median eminence and to preganglionic autonomic cell groups in the medulla and spinal cord.
References
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Journal ArticleDOI
The milk-ejection reflex of the rat: a 20- to 40-fold acceleration in the firing of paraventricular neurones during oxytocin release.
J. B. Wakerley,D. W. Lincoln +1 more
Journal ArticleDOI
Electrophysiological evidence for the activation of supraoptic neurones during the release of oxytocin.
D. W. Lincoln,J. B. Wakerley +1 more
TL;DR: Antidromically identified supraoptic units were recorded in lactating rats anaesthetized with urethane, and their activity was studied during milk ejection evoked by the suckling of the young.
Journal ArticleDOI
Excitation of phasically firing supraoptic neurones during vasopressin release
TL;DR: The neurohypophysial hormones vasopressin and oxytocin are synthesised within separate neurones of the hypothalamic supraoptic and paraventricular nuclei and each hormone can be liberated independently.
Journal ArticleDOI
DISCHARGE PATTERNS OF SUPRAOPTIC AND PARAVENTRICULAR NEURONES IN RATS GIVEN A 2% NaCl SOLUTION INSTEAD OF DRINKING WATER
Journal ArticleDOI
Activity of magnocellular neuroendocrine cells in the hypothalamus of unanaesthetized monkeys. II. Osmosensitivity of functional cell types in the supraoptic nucleus and the internuclear zone.
TL;DR: After antidromic identification, functional cell typing and sensory testing, solutions of varying tonicity into an implanted carotid cannula were injected into the hypothalamus of unanaesthetized, chronically prepared monkeys to determine osmosensitivity.
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