Journal ArticleDOI
Acute nonlymphocytic leukemia with a translocation (1;3)(p36;q21) in an XYY man.
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TLDR
Cytogenetic study of his bone marrow revealed a new chromosomal translocation (1;3)(q36;q21), which has only recently been described in patients with myelodysplastic syndrome.About:
This article is published in Cancer Genetics and Cytogenetics.The article was published on 1986-03-01. It has received 24 citations till now. The article focuses on the topics: Leukemia & XYY syndrome.read more
Citations
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Three new cases of chromosome 3 rearrangement in bands q21 and q26 with abnormal thrombopoiesis bring further evidence to the existence of a 3q21q26 syndrome.
TL;DR: Further evidence is brought to the existence of a cytogenetic syndrome involving bands q21 and q26 simultaneously, which represents a subtype of ANLL, MDS, and MPD, characterized by normal or elevated platelet counts, hyperplasia with dysplasia of megakaryocytes, multilineage involvement, young median age of patients with MDS.
Journal ArticleDOI
Constitutional chromosome aberrations as pathogenetic events in hematologic malignancies.
TL;DR: Cytogenetic studies were performed on 5633 bone marrow specimens from patients with hematologic malignancies from a single institution and Fifty cases of constitutional chromosome aberrations were detected.
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Cytogenetic findings in leukemic cells of 56 patients with constitutional chromosome abnormalities: A cooperative study
TL;DR: Fifty-six patients with a major constitutional chromosome anomaly and a malignant hematologic disorder in whom the chromosomes of the malignant cells were analyzed by banding techniques are reported from a cooperative and retrospective study.
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Diagnostic and prognostic significance of t(1;3)(p36;q21) in the disorders of hematopoiesis
TL;DR: The translocation t(1;3)(p36;q21) is an acquired chromosomal rearrangement associated with myelodysplastic syndromes, which have a high propensity for conversion to refractory acute nonlymphocytic leukemia.
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Transformation of polycythemia vera to acute nonlymphocytic leukemia accompanied by t(1;3)(p36;q21) karyotype
TL;DR: Trilineage hematopoietic abnormalities and a poor response to therapy may represent typical features of patients with t(1;3) rearrangement.
References
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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
TL;DR: The highly specific presence of a chromosomal breakpoint within bcr within Ph'-positive CML patients strongly suggests the involvement of bcr in this type of leukemia.
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The Chromosomal Basis of Human Neoplasia
TL;DR: It is proposed that chromosomal rearrangements play a central role in human neoplasia and may exert their effects through related genomic mechanisms and a translocation could serve to place an oncogene next to an activating DNA sequence, a deletion to eliminate anOncogene repressor, and trisomy to carry extra gene dosage.
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Chromosomal imbalance in the Aniridia-Wilms' tumor association: 11p interstitial deletion.
TL;DR: The genetic heterogeneity of aniridia, the AGR triad, and Wilms' tumor are demonstrated, and Williams' tumor is indicated to be a neoplastic birth defect which can result from a variety of embryologic insults, some of which may be chromosomal or heritable.
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Constitutive fragile sites and cancer.
Jorge J. Yunis,AL Soreng +1 more
TL;DR: Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine, and the locations of 20 sites were correlated with breakpoints that have been related to human malignancy.
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New chromosome techniques in the study of human neoplasia.
TL;DR: Amethopterin synchronization of bone marrow and lymph node cells makes it possible to obtain well banded and elongated metaphases and prometaphases in the majority of patients with leukemia and lymphoma.