Journal ArticleDOI
Acute-phase protein response and survival duration of patients with pancreatic cancer.
J. S. Falconer,Kenneth C. H. Fearon,James A. Ross,R. Elton,Stephen J. Wigmore,O. J. Garden,David Carter +6 more
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Whether certain nutritional indices and the acute‐phase protein response are prognostic factors independent of disease stage for patients with unresectable pancreatic cancer are determined.Abstract:
Background. Current methods to predict survival duration of patients with pancreatic cancer are limited. The aim of this study was to determine whether certain nutritional indices and the acute-phase protein response are prognostic factors independent of disease stage for patients with unresectable pancreatic cancer. Methods. Variables at the time of diagnosis of 102 patients with unresectable pancreatic cancer were entered into a Cox's proportional hazards model. Included in the analysis were the serum concentration of C-reactive protein (CRP) and albumin, the extent of weight loss, age, sex, and disease stage (International Union Against Cancer criteria). Results. A multivariate analysis in which each factor was adjusted for the influence of the other factors revealed the patient age, disease stage, serum albumin, and serum CRP to be independent predictors of survival. The presence of an acute-phase protein response was the most significant independent predictor of survival duration. The median survival of those with an acute-phase protein response (CRP > 10 mg/L, n = 45) was 66 days compared with 222 days for those with no acute-phase protein response (n = 57, P = 0.001, Mann-Whitney Utest). Conclusion. The acute-phase protein response is a useful prognostic indicator for patients with unresectable pancreatic cancer. Moreover, the metabolic disturbances associated with an acute-phase protein response of patients with pancreatic cancer may be a worthwhile therapeutic target. Cancer 1995 ;75 :2077-82.read more
Citations
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Mechanisms of Cancer Cachexia
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Cachexia in cancer patients
TL;DR: Clinical studies in cancer patients have shown that nutritional supplementation can be effective when combined with agents that attenuate the action of tumour factors and modifiers of the central effects on appetite might also show promise.
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Role of systemic inflammatory response in predicting survival in patients with primary operable cancer
TL;DR: Good evidence is demonstrated that there is now good evidence that preoperative measures of the systemic inflammatory response predict cancer survival, independent of tumor stage, in primary operable cancer.
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Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis
TL;DR: The 3-factor profile (weight loss, reduced food intake, and systemic inflammation) identifies patients with both adverse function and prognosis and applies particularly to cachectic patients with localized disease.
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Elevated Biomarkers of Inflammation Are Associated With Reduced Survival Among Breast Cancer Patients
Brandon L. Pierce,Rachel Ballard-Barbash,Leslie R. Bernstein,Richard Baumgartner,Marian L. Neuhouser,Mark H. Wener,Kathy B. Baumgartner,Frank D. Gilliland,Bess Sorensen,Anne McTiernan,Cornelia M. Ulrich +10 more
TL;DR: Circulating SAA and CRP may be important prognostic markers for long-term survival in breast cancer patients, independent of race, tumor stage, race, and body mass index.
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Prognostic effect of weight loss prior tochemotherapy in cancer patients
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