Journal ArticleDOI
Adhesion molecules contribute to ischemia and reperfusion-induced injury in the isolated rat lung.
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TLDR
Leukocyte adherence in the pulmonary, microvasculature and subsequent permeability increase after I/R is dependent on the integrin CD18, its endothelial cell ligand intercellular adhesion molecule 1, and the endothelialcell rolling factor P-selectin but not the leukocyte rolling factor L- selectin.Abstract:
Leukocyte adherence to the endothelium after ischemia and reperfusion contributes to microvascular injury in most organs. The purpose of this study was to evaluate the leukocyte and endothelial cel...read more
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Journal ArticleDOI
Ischemia-reperfusion-induced lung injury.
TL;DR: Better understanding of the mechanisms of ischemia-reperfusion injury, improvements in the technique of lung preservation, and the development of a new preservation solution specifically for the lung have been associated with a reduction in the incidence of primary graft failure from approximately 30 to 15% or less.
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Ischemia-reperfusion injury.
A Seekamp,P A Ward +1 more
TL;DR: In this article, a rat hind limb following ischemia-reperfusion of the hind limb resulted in increased vascular permeability and hemorrhage in skeletal muscle as well as distant organ injury.
Journal ArticleDOI
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
TL;DR: Early identification and aggressive resuscitation aimed at correcting continued elevation in serum lactate improves survival and reduces complications in severely injured trauma patients and persistent OH is associated with higher rates of RC, MSOF, and death after severe trauma.
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Neutrophil Migration Mechanisms, with an Emphasis on the Pulmonary Vasculature
James G. Wagner,Robert A. Roth +1 more
TL;DR: This work reviews general mechanisms of TEM of PMNs and discusses the nature of PMN recruitment in several models of airway inflammation that illustrate how various stimuli elicit different responses.
Journal ArticleDOI
Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome.
Shiraz A. Daud,Roger D. Yusen,Bryan F. Meyers,Murali M. Chakinala,Michael J. Walter,Aviva Aloush,G. Alexander Patterson,Elbert P. Trulock,Ramsey R. Hachem +8 more
TL;DR: Primary graft dysfunction is associated with an increased risk of bronchiolitis obliterans syndrome independent of acute rejection, lymphocytic bronchitis, and community-acquired respiratory viral infections, and this risk is directly related to the severity of primary graft dysfunction.
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