ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP.
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TLDR
It is shown that both the cyclase and CD38 can also catalyze the exchange of the nicotinamide group of NADP++ with nicotinic acid (NA), a metabolite previously shown to be potent in Ca2+2+ mobilization.About:
This article is published in Journal of Biological Chemistry.The article was published on 1995-12-22 and is currently open access. It has received 417 citations till now. The article focuses on the topics: ADP-ribosyl Cyclase & NAD+ kinase.read more
Citations
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Journal ArticleDOI
NAD+ metabolism in health and disease.
TL;DR: Nicotinamide riboside, the recently discovered nucleoside precursor of NAD(+ in eukaryotic systems, might have advantages as a therapy to elevate NAD(+) without inhibiting sirtuins, which is associated with high-dose nicotinamide, or incurring the unpleasant side-effects of high- dose nicotinic acid.
Journal ArticleDOI
Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology
Fabio Malavasi,Silvia Deaglio,Ada Funaro,Enza Ferrero,Alberto L. Horenstein,Erika Ortolan,Tiziana Vaisitti,Semra Aydin +7 more
TL;DR: CD38 is a powerful disease marker for human leukemias and myelomas, is directly involved in the pathogenesis and outcome of human immunodeficiency virus infection and chronic lymphocytic leukemia, and controls insulin release and the development of diabetes.
Journal ArticleDOI
Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition
Katrina L. Bogan,Charles Brenner +1 more
TL;DR: Prospects for human nicotinamide riboside supplementation are presented and areas for future research are proposed to enhance reverse cholesterol transport and protect against neurological degeneration.
Journal ArticleDOI
Generation, control, and processing of cellular calcium signals.
TL;DR: Referee: Guiseppe Inesi, M.D., Ph.D.
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово, Россия
S. V. Ivanov,A. N. Sumin,Y. V. Kazachek,D. E. Philipiev,S. M. Gusev,E. S. Malyshenko,L. S. Barbarash +6 more
TL;DR: The outcomes of CAD surgical treatment were improved in this group of patients due to the implementation of a mul-assisted revascularization of coronary and non-coronary arteries.
References
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Journal ArticleDOI
Inositol trisphosphate and calcium signalling
TL;DR: Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle.
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Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38
Maureen Howard,J C Grimaldi,J. F. Bazan,Frances E. Lund,Leopoldo Santos-Argumedo,R. M. E. Parkhouse,Timothy F. Walseth,Hon Cheung Lee +7 more
TL;DR: Soluble CD38 catalyzed the formation and hydrolysis of cadPR when added to NAD+.
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Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose.
TL;DR: Cyclic ADP-ribose, a metabolite with potent Ca(2+)-releasing properties, appears to act by way of the CICR mechanism and may thus be an endogenous modulator of C ICR.
Journal ArticleDOI
Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.
TL;DR: It is found that a soluble egg factor converts NAD into a highly active metabolite that releases Ca2+ without a lag, and this metabolite was purified to homogeneity by high pressure liquid chromatography and produced half-maximal Ca2 + release at about 40 nM.
Journal ArticleDOI
Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity.
TL;DR: Structural evidence is presented indicating that the metabolite is a cyclized ADP-ribose having an N-glycosyl linkage between the anomeric carbon of the terminal ribose unit and the N6-amino group of the adenine moiety, thus providing strong support for the cyclic structure.
Related Papers (5)
A Derivative of NADP Mobilizes Calcium Stores Insensitive to Inositol Trisphosphate and Cyclic ADP-ribose (∗)
Hon Cheung Lee,Robert Aarhus +1 more