Adrenergic effects on the biology of the adult mammalian cardiocyte.
TLDR
These results constitute the initial demonstration at the cellular level that adrenergic stimulation leads to cyclic AMP-mediated calcium overload of the cell, with a resultant decrease in synthetic activity and/or viability.Abstract:
BACKGROUNDTo delineate the mechanism(s) of catecholamine-mediated cardiac toxicity, we exposed cultures of adult cardiac muscle cells, or cardiocytes, to a broad range of norepinephrine concentrations.METHODS AND RESULTSNorepinephrine stimulation resulted in a concentration-dependent decrease in cardiocyte viability, as demonstrated by a significant decrease in viable rod-shaped cells and a significant release of creatine kinase from cells in norepinephrine-treated cultures. Norepinephrine-mediated cell toxicity was attenuated significantly by beta-adrenoceptor blockade and mimicked by selective stimulation of the beta-adrenoceptor, whereas the effects mediated by the alpha-adrenoceptor were relatively less apparent. When norepinephrine stimulation was examined in terms of cardiocyte anabolic activity, there was a concentration-dependent decrease in the incorporation of [3H]phenylalanine and [3H]uridine into cytoplasmic protein and nuclear RNA, respectively. The decrease in cytoplasmic labeling was largel...read more
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The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
Milton Packer,Michael R. Bristow,Jay N. Cohn,Wilson S. Colucci,Michael B. Fowler,Edward M. Gilbert,Neil H. Shusterman +6 more
TL;DR: Carvedilol reduces the risk or death as well as the risk of hospitalization for cardiovascular causes in patients with heart failure who are receiving treatment with digoxin, diuretics, and an angiotensin-converting-enzyme inhibitor.
Journal Article
The Effect of Carvedilol on Morbidity and Mortality in Patients With Chronic Heart Failure
Milton Packer,Michael R. Bristow,Jay N. Cohn,Wilson S. Colucci,Michael B. Fowler,Edward M. Gilbert,Neil H. Shusterman +6 more
TL;DR: In this paper, a double-blind, placebo-controlled, stratified program, in which patients were assigned to one of four treatment protocols on the basis of their exercise capacity, was presented.
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Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
Ilan S. Wittstein,David R. Thiemann,Joao A.C. Lima,Kenneth L. Baughman,Steven P. Schulman,Gary Gerstenblith,Katherine C. Wu,Jeffrey J. Rade,Trinity J. Bivalacqua,Hunter C. Champion +9 more
TL;DR: Emotional stress can precipitate severe, reversible left ventricular dysfunction in patients without coronary disease andaggerated sympathetic stimulation is probably central to the cause of this syndrome.
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Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review.
TL;DR: Clinicians should consider this syndrome in the differential diagnosis of patients presenting with chest pain, especially in post-menopausal women with a recent history of emotional or physical stress.
Journal ArticleDOI
Carvedilol Produces Dose-Related Improvements in Left Ventricular Function and Survival in Subjects With Chronic Heart Failure
Michael R. Bristow,Edward M. Gilbert,William T. Abraham,Kirkwood F. Adams,Michael B. Fowler,Ray E. Hershberger,Spencer H. Kubo,Kenneth A. Narahara,Henry Ingersoll,Steven K. Krueger,Sarah Young,Neil H. Shusterman +11 more
TL;DR: In subjects with mild to moderate heart failure from systolic dysfunction, carvedilol produced dose-related improvements in LV function and dose- related reductions in mortality and hospitalization rate and was generally well tolerated.
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