Advantage of Applying OSC to 1 H NMR-Based Metabonomic Data of Celiac Disease
Mostafa Rezaei-Tavirani,Fariba Fathi,Fatemeh Darvizeh,Mohamad Reza Zali,Mohamad Rostami Nejad,Kamran Rostami,Mohsen Tafazzoli,Afsaneh Arefi Oskouie,Seyed Abdolreza Mortazavi-Tabatabaei +8 more
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TLDR
The OSC, a filtering method for minimization of inter- and intra-spectrometer variations that influence on data acquisition, was applied to biofluid NMR data of CD patients and four metabolites are introduced as CD biomarkers.Abstract:
Background
Celiac disease (CD) is a disorder associated with body reaction to gluten. After the gluten intake, an immune reaction against the protein occurs and damages villi of small intestine in celiac patients gradually.read more
Citations
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References
More filters
Journal ArticleDOI
Principal component analysis
TL;DR: Principal Component Analysis is a multivariate exploratory analysis method useful to separate systematic variation from noise and to define a space of reduced dimensions that preserve noise.
Journal ArticleDOI
Modified Spin‐Echo Method for Measuring Nuclear Relaxation Times
S. Meiboom,D. Gill +1 more
TL;DR: In this article, a spin echo method adapted to the measurement of long nuclear relaxation times (T2) in liquids is described, and the pulse sequence is identical to the one proposed by Carr and Purcell, but the rf of the successive pulses is coherent, and a phase shift of 90° is introduced in the first pulse.
Journal ArticleDOI
'metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological nmr spectroscopic data
TL;DR: Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data by using NMR data from Xenobiotica.
Journal ArticleDOI
The Collinearity Problem in Linear Regression. The Partial Least Squares (PLS) Approach to Generalized Inverses
TL;DR: In this article, the use of Partial Least Squares (PLS) for handling collinearities among the independent variables X in multiple regression is discussed, and successive estimates are obtained using the residuals from previous rank as a new dependent variable y.
Journal ArticleDOI
Orthogonal projections to latent structures (O-PLS)
Johan Trygg,Svante Wold +1 more
TL;DR: In this article, a generic preprocessing method for multivariate data, called orthogonal projections to latent structures (O-PLS), is described, which removes variation from X (descriptor variables) that is not correlated to Y (property variables, e.g. yield, cost or toxicity).
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