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Journal ArticleDOI

Alterations of tendons in patients with diabetes mellitus: a systematic review

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TLDR
In this paper, a systematic review of observational studies which analyse tendon alterations in patients with diabetes mellitus compared with healthy individuals was performed, with no language restriction, using the databases of PubMed/Medline, BIREME, CINAHL, LILACS and Cochrane, as well as the references found in these studies.
Abstract
Aims To perform a systematic review of observational studies which analyse tendon alterations in patients with diabetes mellitus compared with healthy individuals. Methods Data collection was performed, with no language restriction, using the databases of PubMed/Medline, BIREME, CINAHL, LILACS and Cochrane, as well as the references found in these studies. Three reviewers performed independent extractions of articles. Subsequently, these reviewers analysed the articles, focusing on their methodological quality, using the appropriate scale to evaluate observational studies from the Agency for Healthcare Research and Quality. Results Six articles were included in the analysis. Of these, four had used ultrasonographic diagnostics, one computed tomographyandonemagneticresonanceimaging.Thepatientpoolcomprised396individuals.Allthearticlesevaluatedtendon thickness and presented heterogeneous results. Two articles stated thickening or increased volume of the tendons in diabetic people,onearticledidnotreportanyalteration,thefourthfailedtodetermineanyalterationsandthefifthshowedthinningofthe tendons.Thearrangementofcollagenfibrilsandthepresenceofcalcificationwereanalysedinonlyonearticle(n = 80),showing that 88.10% (n = 68) of individuals with diabetes presented disorientation of collagen fibril arrangement, while only 10% (n = 1) of healthy individuals presented this condition. Regarding tendon calcification, the article showed diabetic individuals with higher values than healthy individuals. Conclusions Allthearticlesindicatedsomerelationbetweendiabetesmellitusandtendonalterationsinhumanbeings,butdue to methodological drawbacks, this association could not be sustained. Diabet. Med. 28, 886‐895 (2011)

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Is there an association between tendinopathy and diabetes mellitus? A systematic review with meta-analysis

TL;DR: Findings provide strong evidence that diabetes is associated with higher risk of tendinopathy, which is clinically relevant as tend inopathy may affect adherence to exercise interventions for diabetes.
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The Influence of Diabetes Mellitus on Clinical and Structural Outcomes After Arthroscopic Rotator Cuff Repair

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The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms

TL;DR: Increasing evidence from the clinic and the laboratory supports an adverse effect of DM on the development, severity, and therapeutic outcomes for OA, which may shed light on general mechanisms of OA pathogenesis.
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Chronic Achilles Tendon Disorders: Tendinopathy and Chronic Rupture.

TL;DR: Chronic Achilles tendon disorders are debated and evidence-based medicine treatment strategies are discussed.
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Biochemical and anisotropical properties of tendons

TL;DR: The objective of this study was to present a review of the composition and organization of the ECM of tendons and to highlight the importance of the anisotropic optical properties in the study of alterations in theECM.
References
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Systems to Rate the Strength of Scientific Evidence: Summary

TL;DR: Systematic approaches to assessing the strength of scientific evidence allow evaluation of either individual articles or entire bodies of research on a particular subject, for use in making evidence-based health-care decisions.
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Are ultrasound and magnetic resonance imaging of value in assessment of Achilles tendon disorders? A two year prospective study

TL;DR: US and MRI show only moderate correlation with clinical assessment of chronic Achilles tendinopathy, and graded MRI appearance was associated with clinical outcome but US was not.
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Imaging in chronic achilles tendinopathy: a comparison of ultrasonography, magnetic resonance imaging and surgical findings in 27 histologically verified cases

TL;DR: Comparisons of ultrasonography and MRI in chronic achilles tendinopathy with regard to the nature and severity of the lesion suggest these methods give similar information and may have their greatest potential as prognostic instruments.
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Lumbar interlaminar epidural injections in managing chronic low back and lower extremity pain: a systematic review.

TL;DR: The evidence based on this systematic review is limited for blind interlaminar epidurals in managing all types of pain except for short-term relief of pain secondary to disc herniation and radiculitis.
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