Journal ArticleDOI
Aluminum toxicity to the brain.
TLDR
The evidence thus far indicates that aluminum is toxic to the brain and it is probable that it has a pathogenic role in Alzheimer's disease.About:
This article is published in Science of The Total Environment.The article was published on 1988-04-01. It has received 47 citations till now. The article focuses on the topics: Senile plaques.read more
Citations
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Journal ArticleDOI
Hippocampal tin, aluminum and zinc in Alzheimer's disease
TL;DR: It is postulated that displacement of hippocampal zinc by heavy metals may be important in producing clinical memory disturbance, and analysis of the CA1 region, rather than of the dentate gyrus, would have been preferable.
Journal ArticleDOI
Chronic Aluminum Intake Causes Alzheimer's Disease: Applying Sir Austin Bradford Hill's Causality Criteria
TL;DR: The causality analysis demonstrates that chronic aluminum intake causes AD, a human form of chronic aluminum neurotoxicity.
Journal ArticleDOI
Aluminum and chronic renal failure: sources, absorption, transport, and toxicity
Michael R. Wills,John Savory +1 more
TL;DR: In patients with end-stage chronic renal failure, particularly in those on treatment by hemodialysis, the accumulation of aluminum in bone, brain, and other tissues is associated with toxic sequelae and an increased brain content of aluminum appears to be the major etiological factor in the development of a neurological syndrome.
Journal Article
Would decreased aluminum ingestion reduce the incidence of Alzheimer's disease?
TL;DR: It is hypothesized that a public health effort to restrict human ingestion of aluminum would reduce the incidence of this common chronic illness in the elderly.
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Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease.
TL;DR: In a comparison between the healthy and Alzheimer patients' concentration data using statistical treatment these elements showed difference as a function of the Alzheimer disease (AD).
References
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Journal ArticleDOI
The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
TL;DR: The expectation of mental disorder shows a steep increase with advancing chronological age, and beyond 75 years a large part of this increase is accounted for by disorders associated with degenerative changes in the central nervous system for which the authors lack remedies at the present time.
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The dialysis encephalopathy syndrome. Possible aluminum intoxication.
TL;DR: The fact that brain gray-matter aluminum was higher in all patients with the dialysis-associated encephalopathy syndrome than any of the control subjects or other uremic patients on dialysis suggests that this syndrome may be due to aluminum in intoxication.
Journal ArticleDOI
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.
Colin L. Masters,Gerhard Multhaup,Gail Simms,J Pottgiesser,Ralph N. Martins,Konrad Beyreuther +5 more
TL;DR: The amyloid of Alzheimer's disease is similar in subunit size, composition but not sequence to the scrapie‐associated fibril and its constituent polypeptides, and the sequence and composition of NFT are not homologous to those of any of the known components of normal neurofilaments.
Journal ArticleDOI
Alzheimer's Disease: X-Ray Spectrometric Evidence of Aluminum Accumulation in Neurofibrillary Tangle-Bearing Neurons
Daniel P. Perl,Arnold R. Brody +1 more
TL;DR: The elemental content of neurons of the hippocampus was studied in autopsy-derived brain tissue from three cases of senile dementia (Alzheimer type) and three nondemented elderly controls to suggest that the association of aluminum to Alzheimer's disease extends to the neuronal level.
Journal ArticleDOI
Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration.
TL;DR: In this article, aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease, which is an important pathological finding in senile and presenile dementia of the Alzheimer type.
Related Papers (5)
Alzheimer's Disease: X-Ray Spectrometric Evidence of Aluminum Accumulation in Neurofibrillary Tangle-Bearing Neurons
Daniel P. Perl,Arnold R. Brody +1 more