An Improved Protocol for Biginelli Reaction
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In this article, a low catalyst loading, reduced reaction time and operational simplicity are the main highlights of a prototype protocol for the Biginelli reaction under microwave heating, which was found active in the synthesis of 30 different biologically active compounds.Abstract:
[Hmim][Tfa] was used as catalyst for the
Biginelli reaction under microwave heating. Low catalyst loading, reduced
reaction time and operational simplicity are the main highlights of this
protocol. The proposed protocol was found active in the synthesis of 30
different biologically active compounds.read more
Citations
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[bmim(SO3H)][OTf]/[bmim][X] and Zn(NTf2)2/[bmim][X] (X = PF6 and BF4); efficient catalytic systems for the synthesis of tetrahydropyrimidin-ones (-thiones) via the Biginelli reaction
TL;DR: In this paper, a facile, high yielding, and simple method for the synthesis of a library of dihydropyrimidinones (and -thiones) via the one-pot Biginelli reaction of aldehydes is reported.
Journal ArticleDOI
The Beneficial Sinergy of MW Irradiation and Ionic Liquids in Catalysis of Organic Reactions
TL;DR: In this paper, the literature data of the last 15 years concerning selected reactions are presented, highlighting the importance of microwave (MW) technology coupled with ionic liquids, as both solvents and catalysts.
Journal ArticleDOI
Rice Husk SiO 2 (NPs) Supported-BO 3 H 3 :A Highly Active, Solvent-Free and Recyclable Catalyst to Dihydropyrimidin-2(1 H )ones- (Thiones) and Coumarin-3-Carboxylic Acid Synthesis
TL;DR: In this paper, the authors used Lewis acid catalyst RHA-SiO2(NPs)-BO3H3 derived from the agro-waste of rice husk, a heterogeneous catalyst for important organic scaffold synthesis.
References
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Biologically active dihydropyrimidones of the Biginelli-type--a literature survey.
TL;DR: This review highlights recent developments in the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones with a focus on the DHPMs recently developed as calcium channel modulators, alpha(1a) adrenoceptor-selective antagonists and compounds that target the mitotic machinery.
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Strategies for Innovation in Multicomponent Reaction Design
TL;DR: This Account provides several examples that illustrate the use of SRR with known MCRs as starting points for synthetic innovation in this area, and explores strategies for engineering improvements into known M CRs, either by increasing the dimensionality, broadening the scope of useful input structures, or both.
Related Papers (5)
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