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Annotation: the analysis of variance and the analysis of causes.
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This article is published in American Journal of Human Genetics.The article was published on 1974-05-01 and is currently open access. It has received 489 citations till now.read more
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Heritability in the genomics era — concepts and misconceptions
TL;DR: This work has shown that despite continuous misunderstandings and controversies over its use and application, heritability remains key to the response to selection in evolutionary biology and agriculture, and to the prediction of disease risk in medicine.
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How Do Risk Factors Work Together? Mediators, Moderators, and Independent, Overlapping, and Proxy Risk Factors
TL;DR: Classifying putative risk factors into these qualitatively different types can help identify high-risk individuals in need of preventive interventions and can help inform the content of such interventions.
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Evolution of phenotypic plasticity: where are we going now?
TL;DR: Some areas of research, such the study of the quantitative genetic underpinning of plasticity, have been either settled in broad outline or superseded by new approaches and questions, and issues, such as the costs, are currently at the forefront of research in this field.
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Epigenetics and the biological definition of gene x environment interactions.
TL;DR: This review focuses on the enduring effects of naturally occurring variations in maternal care on gene expression and phenotype to provide an example of environmentally driven plasticity at the level of the DNA, revealing the interdependence of gene and environmental in the regulation of phenotype.
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Early developmental conditioning of later health and disease: physiology or pathophysiology?
Mark A. Hanson,Peter D. Gluckman +1 more
TL;DR: The extent to which DOHaD represents the result of the physiological processes of developmental plasticity, which may have potential adverse consequences in terms of NCD risk later, or whether it is the manifestation of pathophysiological processes acting in early life but only becoming apparent as disease later?