Journal ArticleDOI
Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri.
subeki subeki,Hideyuki Matsuura,Kosaku Takahashi,Masahiro Yamasaki,Osamu Yamato,Yoshimitsu Maede,Ken Katakura,Sumiko Kobayashi,Trimurningsih Trimurningsih,Chairul Chairul,Teruhiko Yoshihara +10 more
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Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6- O-luteoyl -alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg /mL against Plasmodium falciparum in vitro.Abstract:
Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg/mL against Plasmodium falciparum in vitro. The known compounds beta-glucogallin (2), quercetin 3-O-beta-d-glucopyranosyl-(2-->1)-O-beta-d-xylopyranoside (3), beta-sitosterol, and gallic acid were also isolated. Structures of these compounds were elucidated on the basis of their chemical and spectroscopic data.read more
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Antimalarials from nature
TL;DR: Recent advances in antimalarial drug discovery from natural sources are presented, including plant extracts, and compounds isolated from plants, bacteria, fungi and marine organisms, which offer new and novel scaffolds for development as antimalarials.
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Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review
TL;DR: Studies relating to chemical characteristics and structural properties of the bioactive phytochemicals found in P. niruri are very useful for further research on this plant as many of the phytochemistryicals have shown preclinical therapeutic efficacies for a wide range of human diseases, including HIV/AIDS and hepatitis B.
Journal ArticleDOI
Canine babesiosis: from molecular taxonomy to control
TL;DR: The diagnosis of canine babesiosis by traditional, molecular and serological methods is reviewed, together with recent advances in understanding of the pathophysiology of piroplasmosis, and of the treatment and prevention of this disease.
Journal ArticleDOI
Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use
TL;DR: This paper surveyed the most frequently used plants in jamu that have also been investigated regarding their constituents and pharmacological effects and gave comprehensive views that can be used in its future development for the further improvement of its utility in curing illnesses and maintaining good health.
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Antimalarial compounds isolated from plants used in traditional medicine.
TL;DR: Ethnopharmacological approaches appear to be a promising way to find plant metabolites that could be used as templates for designing new derivatives with improved properties and can play a role in the development of new antimalarial drugs.
References
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Journal ArticleDOI
Human malaria parasites in continuous culture
William Trager,James B. Jensen +1 more
TL;DR: Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen.
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Synchronization of Plasmodium falciparum erythrocytic stages in culture.
TL;DR: Synchronous development of the erythrocytic stages of a human malaria parasite, Plasmodium falciparum, in culture was accomplished by suspending cultured parasites in 5% D-sorbitol and subsequent reintroduction into culture.
Journal ArticleDOI
Neurons selective for orientation and binocular disparity in the visual Wulst of the barn owl (Tyto alba)
TL;DR: The visual response properties of single neurons in the owl's visual Wulst suggest that this forebrain structure is an analog of the mammalian visual cortex.
Journal ArticleDOI
Antihepatotoxic principles of Phyllanthus niruri herbs.
K. V. Syamasundar,Bikram Singh,Raghunath S. Thakur,Akhtar Husain,Kiso Yoshinobu,Hikino Hiroshi +5 more
TL;DR: Among phyllanthin, hypophyllanth in, triacontanal and tricontanol isolated from a hexane extract of Phyllanthus niruri, phyll anthin and hypophyLLanthin protected against carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes.
Journal ArticleDOI
Niruriside, a new HIV REV/RRE binding inhibitor from Phyllanthus niruri.
Jingfang Qian-Cutrone,Stella Huang,John J. Trimble,Hui Li,Pin-Fang Lin,M. Alam,Steven E. Klohr,Kathleen F. Kadow +7 more
TL;DR: Niruriside showed specific inhibitory activity against the binding of REV protein to RRE RNA with an IC50 value of 3.3 microM; however, nirur iside did not protect CEM-SS cells from acute HIV infection at concentrations up to 260 microM using an XTT dye reduction assay.